Calculated free energy (ΔG) of synthesized compounds binding with EGFR^T790M.

Compound	ΔG [kcal mol−1]	Compound	ΔG [kcal mol−1]
5a	−78.53	13	−93.30
5b	−82.40	14a	−86.89
6a	−82.32	14b	−94.74
6b	−84.74	15	−82.06
7	−70.72	16	−91.70
8	−84.27	17	−95.80
9	−86.18	18	−95.07
10	−85.42	Erlotinib	−82.77