TABLE 5.

FMDV polyprotein cleavage site variability^a

Junc- tion	Common amino acids for serotype
	ALL (n = 133)									SAT (n = 16)									A (n = 46)									O (n = 23)									C (n = 7)									Asia (n = 6)
L/1A	R	K	L	K	*	G	A	G	Q	L	F	L	R	*	G	A	G	Q	R	K	L	K	*	G	A	G	Q	R	K	L	K	*	G	A	G	Q	R	K	L	K	*	G	A	G	Q	K	R	L	K	*	G	A	G
	K46	R46	V3	R36					H3	A1	Y2	V2	K2					H1	K9	R10							H1	K8	R7		R2						Q2			R1
	L15	F15								T1									Q4	N1
	T1	Y3																	W1
	Q6	N1
	A2
	W1
1A/1B	A	L	L	A	*	D	K	K	T	A	L	L	A	*	D	K	K	T	A	L	L	A	*	D	K	K	T	A	L	L	A	*	D	K	K	T	A	L	L	A	*	D	K	K	T	A	L	L	A	*	D	K	K
	T1																											T1
1B/1C	P	S	K	E	*	G	I	F	P	P	A	K	Q	*	G	I	L	P	P	S	K	E	*	G	I	F	P	P	S	K	E	*	G	I	F	P	P	S	K	E	*	G	I	F	P	P	S	K	E	*	G	I	V
		A10		Q17			V1	V21			S3		E2				I6					Q1			V10
		V2						I7			V2						V2
		G2						L7			G1						F1
		M1									M1
1C/1D	P	R	T	Q	*	T	T	S	T	P	S	R	Q	*	T	T	S	A	P	R	Q	Q	*	T	T	A	T	A	R	T	Q	*	T	T	S	A	A	R	Q	Q	*	T	T	T	T	A	R	Q	Q	*	T	T	T
	A67	S8	Q27	E14				A43	A51		V3	T2						V2			P10					T7	V7			A9	E10					T6			R2					A3	A1			R2
	T1	V5	R26					T23	V9		A2	A2									S10					S4	A3			R5						P1
		A2	A16						P2		T2										T7									V1
		T2	P14						L1		C1										A3
		C1	S12						S1												L1
			V1																		R1
			L1
1D/2A	P	A	K	Q	*	L	L	N	F	P	A	K	Q	*	L	C	N	F	P	A	K	Q	*	L	L	N	F	P	V	K	Q	*	T	L	N	F	P	A	K	Q	*	L	L	N	F	P	E	K	Q	*	V	L	N
	V5	G1	R1			S1	C12	S1	C1	V3	E6				M3	L1	S1	C1		E8	R3								A2				L7					E1					S2								L1
		E25				T19	S3				D2					A1					G1								T2																						T1
		T2				A2	A1				V1					S1					T1																														A1
		S1				V4	F1									F1					V1
		V38				M3
		K1
		D2
2A/2B*	S	N	P	G	*	P	F	F	F	S	N	P	G	*	P	F	F	F	S	N	P	G	*	P	F	F	F	S	N	P	G	*	P	F	F	F	S	N	P	G	*	P	F	F	F	S	N	P	G	*	P	F	F
	P2		L1	R1			L2	S1								L2			P1
2B/2C	A	E	K	Q	*	L	K	A	R	A	E	K	Q	*	L	K	A	R	A	E	K	Q	*	L	K	A	R	A	E	K	Q	*	L	K	A	R	A	E	K	Q	*	L	K	A	R	A	E	K	Q	*	L	K	A
							R3																		R1																		R1
2C/3A	I	F	K	Q	*	I	S	I	P	I	F	K	Q	*	I	S	I	P	I	F	K	Q	*	I	S	I	P	I	F	K	Q	*	I	S	I	P	I	F	K	Q	*	I	S	I	P	I	F	K	Q	*	I	S	I
				L1				L2									L2																		T1																		V1
								T3
								V1
3A/3B	P	Q	A	E	*	G	P	Y	A	P	Q	A	E	*	G	P	Y	A	P	Q	A	E	*	G	P	Y	A	P	Q	A	E	*	G	P	Y	A	P	Q	A	E	*	G	P	Y	A	P	Q	A	E	*	G	P	Y
		R9	T2						T24		K1							T1		R3	T1						T3									T4									T1
		H5							S2		H1									H4																V1
		K1							V1
3B/3C	I	V	T	E	*	S	G	A	P	I	V	T	E	*	S	G	C	P	I	V	T	E	*	S	G	A	P	I	V		E	*	S	G	A	P	I	V	T	E	*	S	G	A	P	I	V	T	E	*	S	G	A
						T1		C15							T1		A2
3C/3D	P	H	H	E	*	G	L	I	V	P	H	T	E	*	G	L	V	V	P	H	H	E	*	G	L	I	V	P	H	H	E	*	G	L	I	V	P	H	H	E	*	G	L	I	V	P	H	H	E	*	G	L	I
		Q2	T13					V16	L1			H2					I2	L1									I1								V1
									I2			N1

^aIndividual columns and rows represent FMDV serotypes and protein junctions, respectively. The first line in each row indicates the most frequent amino acid for each position, with alternative amino acids listed below and subscripts indicating the number of isolates with that particular residue. The total number (n) of isolates compared within each serotype is indicated at the top. *, protein cleavage point.