TABLE 6.

Amino acid conservation in FMDV and ERAV L^pro

Position no.a	1	6	30, 31	37	40	42	44-47	51-55	58-63	66, 67	73	75, 76	80
FMDVb	M	C	ME	G	K	F	SRPN	NCWLN	QLFRY	EP	Y	SP	T
FMDV/ERAVc	M							NCWLN	QL				T
Position no.	87	91	93	95	98-102	104	106	108-110	112	114, 115	117, 118	121-124	126	130
FMDV	L	T	L	L	GGPPA	V	W	IK(H/D)	L	TG	GT	RPSE	C	G
FMDV/ERAV		T		L	G PP	V					GT	P		G
Position no.	133-143	145, 146	149-153	156	159, 160	162	164-166	169-173	175	178, 179	183-185	187-189
FMDV	M(C/T)LADFHAGIF	KG	HAVFA	T	GW	A	DDE	YPWTP	P	VL	VPYD	EP
FMDV/ERAV	L DF A	K	HAVF	T	GW		DD	YP TP		VL	PYD

^aNumbers indicate L^pro amino acid positions from the first polyprotein AUG of Dialign-aligned FMDV polyproteins.

^bInvariant L^pro residues among 133 FMDV isolates. The proteolytic active sites C52 and H149 are shown in bold.

^cInvariant L^pro residues between FMDV and ERAV sequences (38).