Trial	Proportion of patients with lacunar mechanism	Proportion of patients with TIA
FASTER 68	25.3%–36.1%	At least 39%
CHANCE 61	Not reported,*	27.9%
POINT 62	Not reported	43.2%
THALES 69	Not reported	9%

^*Liu et al. ⁷⁰ reported that among the total of 5170 subjects in CHANCE, a subgroup of 1089 underwent MR angiography, where 56% had intracranial large vessel stenosis (ICAS) and that there was no treatment effect interaction when comparing ICAS versus other (where the majority might be suspected to be small vessel disease), (p = 0.52).