Table 3.
GRADE evidence profile for PICO3 – In patients with lacunar stroke, does immediate antihypertensive treatment (considering agent and BP target), compared to avoiding this intervention, reduce functional outcome, MACE and other outcomes?
| Certainty assessment | No of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No of studies | Study design | Risk of bias | Inconsist-ency | Indirect-ness | Imprec-ision | Other consider-ations | Interv-ention | Compar-ator | Odds Ratio (95% CI) | Absolute (95% CI) | ||
| Functional Outcome | ||||||||||||
| 4 | Randomised trials | Not serious | Not serious | Not serious | Seriousa | None | NR | NR | OR 0.98 (0.74,1.28),* | 1 fewer per 1000 (from 1 fewer to 1 fewer) *** |
⨁⨁⨁○ Moderate |
CRITICAL |
| OR 0.99 (0.78, 1.27)** | ||||||||||||
| MACE | ||||||||||||
| 2 | Randomised trials | Not serious | Not serious | Not serious | Seriousa | None | 25/321 (7.8%) | 21/359 (5.8%) | OR 1.33 (0.73, 2.44) |
18 more per 1000 (from 15 fewer to 73 more) |
⨁⨁⨁○ Moderate |
CRITICAL |
| Shift in mRS distribution | ||||||||||||
| 2 | Randomised trials | Not serious | Not serious | Not serious | Seriousa | None | -/634 | -/613 | OR 0.98 (0.72, 1.34),* |
1 fewer per 1000 (from 1 fewer to 1 fewer)0 fewer per 1000 (from 0 fewer to 0 fewer) |
⨁⨁⨁○ Moderate |
CRITICAL |
| OR 0.94 (0.80, 1.10)** | ||||||||||||
CI: confidence interval; OR: odds ratio; a Confidence interval crosses the clinical decision threshold.
*
Represents odds ratio for continuing anti-hypertensives (ENOS).
**
Represents odds ratio for transdermal glyceryl trinitrate (ENOS).
***
Represents identical absolute 95% CI for both * and **