Table 1.
Odds ratios of clinical outcomes at 3 months after ischemic stroke according to UA status.
| Analysis | UA
a
|
Q1 |
Q2 |
Q3 |
Q4 |
P for trend
b
|
||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |||
| Primary outcome: mRS 3–6 | ||||||||||
| Univariable model | 1.00 (1.00–1.00) | <0.001 | 1.00 (reference) | 0.50 (0.42–0.58) | <0.001 | 0.42 (0.35–0.49) | <0.001 | 0.40 (0.34–0.48) | <0.001 | <0.001 |
| Multivariable model | 1.00 (1.00–1.00) | 0.029 | 1.00 (reference) | 0.83 (0.67–1.04) | 0.105 | 0.91 (0.72–1.15) | 0.424 | 0.84 (0.65–1.09) | 0.198 | 0.266 |
| Secondary outcomes mRS 2–6 | ||||||||||
| Univariable model | 1.00 (1.00–1.00) | <0.001 | 1.00 (reference) | 0.54 (0.46–0.62) | <0.001 | 0.45 (0.39–0.53) | <0.001 | 0.43 (0.37–0.5) | <0.001 | <0.001 |
| Multivariable model | 1.00 (1.00–1.00) | 0.485 | 1.00 (reference) | 0.91 (0.74–1.11) | 0.337 | 1.02 (0.83–1.25) | 0.863 | 1.00 (0.79–1.25) | 0.986 | 0.782 |
| Ordinal mRS (range 0–6) | ||||||||||
| Univariable model | 1.00 (1.00–1.00) | <0.001 | 1.00 (reference) | 0.55 (0.48–0.63) | <0.001 | 0.47 (0.41–0.54) | <0.001 | 0.42 (0.37–0.48) | <0.001 | <0.001 |
| Multivariable model | 1.02 (1.00–1.03) | 0.081 | 1.00 (reference) | 0.89 (0.77–1.02) | 0.098 | 0.96 (0.82–1.11) | 0.542 | 0.86 (0.73–1.01) | 0.072 | 0.200 |
Q: quintile; OR: odd ratio; CI: confidence interval; mRS: modified Rankin Scale.
ORs and 95% CIs was calculated with the use of the logistic regression model. Q1 level (⩽234 µmol/L) of uric acid was set as the reference.
Multivariable model adjusted for sex, age, recruitment year, BMI, NIHSS Score at admission, hypertension, systolic blood pressure, diastolic blood pressure, diabetes, fasting blood glucose, glycolated hemoglobin, hyperlipidemia, higher levels of triglyceride, high-density lipoprotein, history of transient ischemic attack, smoking, drinking, family history of stroke, history of atrial fibrillation, history of coronary heart disease, history of myocardial infarction, hemoglobin, white blood cell, platelet, hyperbilirubinemia, serum creatinine, fibrinogen, international standard ratio, TOAST type, antiplatelet treatment, anti-coagulation treatment, and NIHSS at discharge.
Uric acid as a continuous variable.
Test for trend based on variable containing median value for each quintile.