Table 1.
Characteristics of the included studies.
| Study ID | Study design | Occlusion site, N (%) | No. of patients (% female) |
Baseline NIHSS, Median (IQR) |
IVT, N (%) |
ENI definition | sICH definition | |||
|---|---|---|---|---|---|---|---|---|---|---|
| EVT | BMM | EVT | BMM | EVT | BMM | |||||
| Cunha et al. 2 | Single-center retrospective cohort | P1: 19 (50%), P2: 16 (42.1%), P3: 3 (7.89%) | 25 (36.0) | 13 (46.2) | 10 (6–14.5) | 8 (5.5–10.0) | 14 (56) | 13 (100) | A minimum four-point score improvement compared to admission NIHSS. | ECASS II |
| Herweh et al. 10 | Multicenter retrospective cohort | P1: 62 (47.69%), distal to P1: 68 (52.3%) | 23 (39.1) | 107 (47.7) | 9 (1–20) | 7 (1–38) | 5 (21.7) | 44 (41.1) | An improvement in NIHSS scores of at least 4 points or reaching 0 points. | Heidelberg Bleeding Classification |
| Maulucci et al. 17 | Multicenter retrospective cohort | P1: 107 (39.9%), P2: 161 (60.1%) | 119 (35.3) | 149 (45.6) | 7 (5–13) | 5 (3–8) | 69 (57.98) | 149 (100) | – | ECASS II |
| Meyer et al. 12 | Multicenter retrospective case-control | P2: 199 (81.9%), P3: 44 (18.1%), fetal variant 15 (6.2%), bilateral 8 (3.3%) | 143 (44.8) | 100 (50.0) | 7 (4–11) | 5 (2–10) | 57 (39.9) | 56 (56.0) | An improvement in NIHSS scores of at least 4 points or reaching 0 points. | ECASS II |
| Nguyen et al. 6 | Multicenter retrospective cohort | P1: 421 (41.2%), P2: 503 (49.2%), P3 (includes 3 P4): 73 (7.1%), fetal PCA: 14 (1.4%), bilateral: 12 (1.2%) | 378 (42.9) | 645 (42.2) | 8 (5–12) | 5 (2–9) | 152 (40.2) | 287 (45.5) | A ⩾ 2-point decrease in (NIHSS) at 24 h or at hospital discharge. | SITS-MOST |
| Sabben et al. 9 | Multicenter retrospective cohort | P1: 188 (25%), P2: 564 (75%) | 167 (47.3) | 585 (42.7) | 8 (5–11) | 6 (3–10) | 90 (53.9) | 467 (79.8) | – | ECASS II |
| Strambo et al. 3 | Single-center retrospective cohort | P1: 34 (32.1%; n = 3 fetal), P2: 72 (67.9%; n = 4 fetal) | 21 (61.9) | 85 (43.5) | 7 (5–8.3) | 7 (4–12.0) | 13 (61.9) | 34 (40) | – | ECASS II |
iPCAO: isolated posterior cerebral artery occlusion; EVT: endovascular thrombectomy; BMM: best medical management; IVT: intravenous thrombolysis; NIHSS: National Institutes of Health Stroke Scale; ENI: early neurological improvement; ECASS II: European Cooperative Acute Stroke Study-II; SITS-MOST: Safe Implementation of Thrombolysis in Stroke-Monitoring Study.