TABLE 2.

Linear mixed effects showing the vascular composite score and significant individual risk factors on WMH burden

Males	Total	Frontal	Temporal	Parietal	Occipital	Deep	Periventricular
VC (Equation 2)	β = 0.02, SE < 0.01, t = 3.63, p < 0.001	β = 0.02, SE < 0.01, t = 3.76, p < 0.001	β = 0.02, SE < 0.01, t = 2.69, p = 0.007	β = 0.02, SE < 0.01, t = 3.20, p = 0.001	β = 0.01, SE < 0.01, t = 1.41, p = 0.16	β = 0.03, SE = 0.02, t = 2.06 p = 0.039	β = 0.34, SE = 0.02, t = 2.00, p = 0.046
Systolic BP (Equation 4)	β = 0.01, SE < 0.01, t = 2.32, p = 0.020	β < 0.01, SE < 0.01, t = 2.14, p = 0.032	β < 0.01, SE < 0.01, t = 1.09, p = 0.27	β = 0.01, SE < 0.01, t = 1.71, p = 0.09	β = 0.02, SE < 0.01, t = 2.69, p = 0.007	β < −0.01, SE = 0.01, t = −0.49, p = 0.63	β = 0.01, SE = 0.02, t = 0.81, p = 0.42
History Of hypertension (Equation 4)	β = 0.27, SE = 0.05, t = 5.18, p < 0.001	β = 0.32, SE = 0.05, t = 6.09, p < 0.001	β = 0.17, SE = 0.05, t = 3.20, p = 0.001	β = 0.23, SE = 0.06, t = 3.19, p = 0.001	β < 0.01, SE = 0.06, t = 0.13, p = 0.89	β = 0.19, SE = 0.06, t = 3.19, p = 0.001	β = 0.15, SE = 0.05, t = 3.26, p = 0.001

Females	Total	Frontal	Temporal	Parietal	Occipital	Deep	Periventricular
VC (Equation 2)	β = 0.04, SE < 0.01, t = 4.05, p < 0.001	β = 0.04, SE < 0.01, t = 3.79, p < 0.001	β = 0.04, SE = 0.01, t = 3.49, p < 0.001	β = 0.03, SE < 0.01, t = 2.80, p = 0.005	β = 0.04, SE = 0.01, t = 3.15, p = 0.002	β = 0.04, SE = 0.03, t = 2.68, p = 0.007	β = 0.05, SE = 0.02, t = 2.73 p = 0.006
Systolic BP (Equation 4)	β < 0.01, SE < 0.01, t = 0.95, p = 0.34	β < 0.01, SE < 0.01, t = 0.43, p = 0.67	β < 0.01, SE < 0.01, t = 1.19, p = 0.23	β < 0.01, SE < 0.01, t = 1.09, p = 0.27	β = 0.01, SE < 0.01, t = 0.20, p = 0.84	β = 0.03, SE = 0.01, t = 2.33, p = 0.019	β = 0.03, SE = 0.02, t = 2.25, p = 0.024
History Of hypertension (Equation 4)	β = 0.12, SE = 0.06, t = 2.10, p = 0.037	β = 0.14, SE = 0.06, t = 2.44, p = 0.015	β = 0.04, SE = 0.06, t = 0.70, p = 0.49	β = 0.10, SE = 0.06, t = 1.82, p = 0.07	β = −0.02, SE = 0.01, t = −0.28, p = 0.78	β = 0.17, SE = 0.06, t = 2.92, p = 0.003	β = 0.14, SE = 0.05, t = 2.72, p = 0.006

Notes: Main effects of age, education, APOE status, and diagnosis can be found in supplementary material.

Abbreviations: History of hypertension, current or past history of high blood pressure, reported as 0 (no history of high blood pressure) or 1 (history of high blood pressure); Systolic BP, current systolic blood pressure, reported as a continuous measure; VC, vascular composite.

Bold values represent results that remained significant after correction for multiple comaprisons.