. 2023 Sep 21;20(1):34–46. doi: 10.1002/alz.13452

TABLE 3.

Models from Equations 3 and 5 showing the main effect of sex WMHs and interaction between sex and each significant risk factor

Interaction models	Total	Frontal	Temporal	Parietal	Occipital	Deep	Periventricular
Sex (Male) (Equation 3)	β = −0.04, SE = 0.04, t = −1.05, p = 0.29	β = −0.14, SE = 0.04, t = −3.57 p < 0.001	β = 0.11, SE = 0.04, t = 2.79, p = 0.005	β = 0.03, SE = 0.04, t = 0.73, p = 0.46	β = 0.22, SE = 0.04, t = 5.23, p < 0.001	β = −0.19, SE = 0.05, t = −3.58, p < 0.001	β < 0.01, SE = 0.03, t = 0.11, p = 0.92
Sex (male):VC (Equation 3)	β = −0.01, SE = 0.01, t = −0.83 p = 0.40	β = −0.01, SE = 0.01, t = −0.52, p = 0.60	β = −0.01, SE = 0.01, t = −1.03, p = 0.30	β < −0.01, SE = 0.01, t = −0.05, p = 0.96	β = −0.02, SE = 0.02, t = −1.40, p = 0.16	β = −0.01, SE = 0.03, t = −0.48, p = 0.63	β = −0.02, SE = 0.03, t = −0.71, p = 0.48
Sex (male): Systolic BP (Equation 5)	β < 0.01, SE < 0.01, t = 1.06, p = .29	β < 0.01, SE < 0.01, t = 0.86, p = .39	β < 0.01, SE < 0.01, t = 0.31, p = .76	β < 0.01, SE < 0.01, t = 1.19, p = .24	β = 0.02, SE < 0.01, t = 2.18, p = .029	β = −0.03, SE = 0.01, t = −2.23, p = .026	β = −0.02, SE = 0.02, t = −1.66, p = .24
Sex (male): History of Hypertension (Equation 5)	β = 0.15, SE = 0.07, t = 1.94, p = 0.052	β = 0.22, SE = 0.09, t = 2.47, p = 0.014	β = 0.13, SE = 0.08, t = 1.65, p = 0.09	β = 0.12, SE = 0.08, t = 1.61, p = 0.11	β = 0.07, SE = 0.08, t = 0.82, p = 0.41	β < −0.01, SE = 0.01, t = −0.06, p = 0.95	β = 0.03, SE = 0.07, t = 0.38, p = 0.70

Interaction models

Total

Frontal

Temporal

Parietal

Occipital

Deep

Periventricular

Sex (Male) (Equation 3)

β = −0.04,

SE = 0.04,

t = −1.05,

p = 0.29

β = −0.14,

SE = 0.04,

t = −3.57

p < 0.001

β = 0.11,

SE = 0.04,

t = 2.79,

p = 0.005

β = 0.03,

SE = 0.04,

t = 0.73,

p = 0.46

β = 0.22,

SE = 0.04,

t = 5.23,

p < 0.001

β = −0.19,

SE = 0.05,

t = −3.58,

p < 0.001

β < 0.01,

SE = 0.03,

t = 0.11,

p = 0.92

Sex (male):VC (Equation 3)

β = −0.01,

SE = 0.01,

t = −0.83

p = 0.40

β = −0.01,

SE = 0.01,

t = −0.52,

p = 0.60

β = −0.01,

SE = 0.01,

t = −1.03,

p = 0.30

β < −0.01,

SE = 0.01,

t = −0.05,

p = 0.96

β = −0.02,

SE = 0.02,

t = −1.40,

p = 0.16

β = −0.01,

SE = 0.03,

t = −0.48,

p = 0.63

β = −0.02,

SE = 0.03,

t = −0.71,

p = 0.48

Sex (male): Systolic BP (Equation 5)

β < 0.01,

SE < 0.01,

t = 1.06,

p = .29

β < 0.01,

SE < 0.01,

t = 0.86,

p = .39

β < 0.01,

SE < 0.01,

t = 0.31,

p = .76

β < 0.01,

SE < 0.01,

t = 1.19,

p = .24

β = 0.02,

SE < 0.01,

t = 2.18,

p = .029

β = −0.03,

SE = 0.01,

t = −2.23,

p = .026

β = −0.02,

SE = 0.02,

t = −1.66,

p = .24

Sex (male): History of Hypertension (Equation 5)

β = 0.15,

SE = 0.07,

t = 1.94,

p = 0.052

β = 0.22,

SE = 0.09,

t = 2.47,

p = 0.014

β = 0.13,

SE = 0.08,

t = 1.65,

p = 0.09

β = 0.12,

SE = 0.08,

t = 1.61,

p = 0.11

β = 0.07,

SE = 0.08,

t = 0.82,

p = 0.41

β < −0.01,

SE = 0.01,

t = −0.06,

p = 0.95

β = 0.03,

SE = 0.07,

t = 0.38,

p = 0.70

Notes: The colon (:) denotes the interaction between sex and each risk factor, vascular composite, systolic blood pressure, and history of hypertension. In all analysis we contrasted males against females, with females as the reference category.

Abbreviations: History of hypertension, current or past history of high blood pressure, reported as 0 (no history of high blood pressure) or 1 (history of high blood pressure); Systolic BP, current systolic blood pressure, reported as a continuous measure; VC, vascular composite.

Bold values represent results that remained significant after correction for multiple comaprisons.