TABLE 3.

Cox regression models showing effect of BBBp on risk of cognitive decline progression (N = 273).

	HR (95% CI)	P
Sex, female	1.63 (1.12;2.36)	0.0099
Log‐QAlb, 10% increase in Qalb	1.08 (1.04;1.13)	0.0003
Alzheimer's disease	2.09 (1.39;3.13)	0.0004
CDR Score = 0.5	2.92 (1.05;8.16)	0.0408
CDR Score = 1	3.23 (1.13;9.21)	0.0286
CDR Score = 2	4.67 (1.62;13.47)	0.0043

Note: The dependent variable was the incidence of CDP within 3 years, and values represent hazard ratios, 95% confidence intervals, and p values. Variables were selected via a forward stepwise algorithm, where the metric of interest was the Akaike information criterion and the scope model was fully adjusted for age, sex, education, hypertension, diabetes, hyperlipidemia, Alzheimer's disease, CDR scale, cerebrovascular burden, and log‐Qalb. In this table we show the final model at the last iteration.

Abbreviations: BBBp, blood‐brain‐barrier permeability; CI, confidence interval; CDR, clinical dementia rating scale; HR, hazard ratio; log‐QAlb, log‐scaled CSF/serum albumin ratio.