TABLE 3.

Correlations between Alzheimer's disease biomarkers and MMSE at baseline and MMSE rate of change controlling for age, sex, education, and clinical status.

Biomarkers	Correlation coefficient	p‐Value
Correlations with MMSE at baseline
N: FDG AD meta‐ROI	0.712	<0.001
N: FDG Lateral temporal ROI	0.709	<0.001
T: Tau lateral temporal ROI	−0.682	<0.001
T: Tau meta‐ROI	−0.628	<0.001
N: MRI AD cortical signature	0.673	<0.001
N: MRI HPV	0.667	<0.001
A: Amyloid centiloid	−0.644	<0.001
Correlations with MMSE annual rate of change
T: Tau lateral temporal ROI	−0.677	<0.001
T: Tau meta‐ROI	−0.669	<0.001
A: Amyloid centiloid	−0.564	0.002
N: FDG lateral temporal ROI	0.498	0.015
N: FDG AD meta‐ROI	0.491	0.018
N: MRI AD cortical signature	0.447	NS
N: MRI HPV	0.438	NS

Abbreviations: A, amyloid; HPV, hippocampal volume; MMSE, mini‐mental state examination; N, neurodegeneration; NS, not significant; AD, Alzheimer's disease; T, tau.