TABLE 2.
Baseline prediction of dementia phenoconversion in iRBD.
| Percent abnormal a | |||||
|---|---|---|---|---|---|
| Test | HR (95% CI) | Parkinsonism‐first | Dementia‐first | p‐Value | |
| Attention domain (any test) | 4.65 (2.49, 8.7) | 26.5 | 64.1 | <0.001 | |
| TMT A | 3.82 (1.91, 7.64) | 15.2 | 42.1 | 0.003 | |
| Stroop interference | 5.62 (2.29, 13.82) | 6.1 | 35.0 | 0.003 | |
| Digit span backward | 5.14 (1.38, 19.17) | 0.0 | 9.4 | 0.073 | |
| Digit span forward | 1.93 (0.97, 3.85) | 12.1 | 22.6 | 0.245 | |
| Executive domain (any test) | 6.05 (2.97, 12.33) | 36.2 | 73.1 | <0.001 | |
| TMT B | 4.62 (2.32, 9.21) | 33.3 | 64.8 | 0.003 | |
| TMT B‐A | 7.86 (3.19, 19.41) | 17.9 | 59.4 | 0.003 | |
| Phonemic fluency | 2.35 (1.06, 5.19) | 9.4 | 19.0 | 0.189 | |
| Semantic fluency | 4.14 (2.19, 7.84) | 8.6 | 28.6 | 0.004 | |
| Memory domain (any test) | 3.26 (1.81, 5.86) | 16.4 | 53.3 | <0.001 | |
| Word list immediate recall | 4.06 (2.01, 8.16) | 11.0 | 35.0 | 0.003 | |
| Word list delayed recall | 2.18 (1.08, 4.39) | 11.3 | 36.8 | 0.003 | |
| Word list recognition | 1.88 (0.84, 4.19) | 4.5 | 20.5 | 0.073 | |
| Visuospatial domain | – | – | – | – | |
| Figure copy | 2.07 (1.06, 4.03) | 14.3 | 31.5 | 0.064 | |
| Language Domain | – | – | – | – | |
| Naming | 6.17 (1.83, 20.79) | 6.9 | 17.4 | 0.460 | |
| MCI | 2.74 (1.42, 5.3) | 30.2 | 58.0 | 0.001 | |
Note: Hazard ratios with 95% confidence intervals are presented according to competing risks regression analysis adjusting for age, sex, education, depression, and study center. Hazard ratios for which the confidence intervals do not cross one (i.e., p < 0.05) are highlighted in bold. Values for the Visuospatial and Language domains are not shown since only one test was available for each domain.
Abbreviations: iRBD, isolated/idiopathic rapid eye movement sleep behavior disorder; MCI, mild cognitive impairment; TMT, Trail Making Test.
a
Impaired testing based on a z‐score cutoff of −1.5.