TABLE 2.

Associations between global cerebral blood flow and cognitive change.

Cognitive domain	Adjusted a St‐β (95% CI)	p value
Global cognitive function	0.172 (0.019 to 0.344)	.026 b
Memory	0.158 (0.000 to 0.326)	.054
Attention/psychomotor speed	0.227 (0.071 to 0.397)	.004 b
Language	0.039 (−0.130 to 0.221)	.619
Executive functioning	0.043 (−0.151 to 0.237)	.611

Note: St‐β values represent standardized regression coefficients. Negative cognitive change scores indicate cognitive decline (change z‐scores were calculated by subtracting z‐scores at baseline from z‐scores at follow‐up).

Abbreviation: CI, confidence interval.

^a Adjusted for age, sex, educational level, participant group, study center, baseline relative WMH volume, and baseline relative brain volume.

^b Remained significant after testing for multiple comparisons.