TABLE 3.

Associations between regional brain cerebral blood flow and cognitive change.

Cognitive domain	Region	Adjusted St‐β a (95% CI)	p value
Global cognitive function	Frontal	0.164 (0.018 to 0.310)	.026 b
	Parietal	0.162 (0.018 to 0.306)	.032 b
	Temporal	0.210 (0.053 to 0.350)	.006 b
	Occipital	0.172 (0.019 to 0.306)	.029 b
Memory	Frontal	0.183 (0.029 to 0.327)	.018 b
	Parietal	0.156 (0.000 to 0.312)	.050
	Temporal	0.200 (0.040 to 0.360)	.014 b
	Occipital	0.110 (−0.055 to 0.275)	.187
Attention/pyschomotor speed	Frontal	0.200 (0.053 to 0.347)	.008 b
	Parietal	0.189 (0.041 to 0.324)	.015 b
	Temporal	0.254 (0.107 to 0.401)	.001 b
	Occipital	0.167 (0.015 to 0.334)	.040 b
Language	Frontal	0.009 (−0.117 to 0.126)	.906
	Parietal	0.043 (−0.097 to 0.183)	.574
	Temporal	0.035 (−0.128 to 0.198)	.654
	Occipital	0.116 (−0.039 to 0.284)	.147
Executive functioning	Frontal	0.049 (−0.098 to 0.196)	.546
	Parietal	0.046 (−0.138 to 0.253)	.555
	Temporal	0.088 (−0.070 to 0.246)	.300
	Occipital	0.088 (−0.088 to 0.286)	.310

Note: β values represent standardized regression coefficients. Negative cognitive change scores indicate cognitive decline (change z‐scores were calculated by subtracting z‐scores at baseline from z‐scores at follow‐up).

Abbreviation: CI, confidence interval.

^a Adjusted for age, sex, educational level, participant group, study center, baseline relative WMH volume, and baseline relative brain volume.

^b Remained significant after testing for multiple comparisons.