TABLE 1.
Characteristics of nested case‐control population.
| All‐cause dementia (n=99,384) | Controls (n=469,920) | |
|---|---|---|
| Sex: Female | 55,105 (55.4) | 275,525 (55.4) |
| Age at index (years, median) | 78 (73.0 to 82.6) | 78 (73.0 to 82.6) |
| Follow‐up (years, median) | 11.1 (7.0 to 14.8) | 18.2 (14.1 to 19.0) |
| Year of diagnosis (median) | 2012 (2008 to 2015) | – |
| Cardiovascular disease (CVD) | 43,006 (43.3) | 185,950 (37.4) |
| Stroke | 7333 (7.4) | 22,046 (4.4) |
| IHD/AMI | 17,819 (17.9) | 79,482 (16.0) |
| OAT/OAC | 39,082 (39.3) | 168,999 (34.0) |
| Diabetes | 10,482 (10.5) | 38,418 (7.7) |
| Hypertension | 61,763 (62.1) | 288,986 (58.2) |
| Dyslipidemia | 28,065 (28.2) | 126,799 (25.5) |
| Educational level | ||
| Low | 51,218 (51.5) | 246,521 (49.6) |
| Medium | 34,009 (34.2) | 172,612 (34.7) |
| High | 12,493 (12.6) | 69,039 (13.9) |
| Unknown | 1664 (1.7) | 8748 (1.8) |
| PPI user (2+ prescriptions) | 21,049 (21.2) | 93,751 (18.9) |
| Age at treatment initiation (years, median) | 68 (62 to 73) | 68 (63 to 73) |
| Duration of treatment (months, median) | 3.7 (0.9 to 21.2) | 3.6 (0.9 to 18.6) |
| One prescription only | 7350 (7.4) | 35,064 (7.1) |
Note. Values are shown either in ‘number of individuals (%)’ or ‘median (first‐third quartile)’. Shown numbers of PPI use include 5 years lag time window.
Abbreviations: AMI, acute myocardial infarction; CVD, cardiovascular disease; IHD, ischemic heart disease; OAT, oral antithrombotic medication; OAC, oral anticoagulants; PPI, proton pump inhibitor.