FIGURE 3.

TDP‐43 seeding activity in olfactory mucosa in different subgroups. Representative curves of TDP43‐SAA from the olfactory mucosa, derived from the average percentage of ThT fluorescence from four replicate reactions (normalized as described in the Methods section) in each subject, grouped according to genetic trait or diagnosis. C9orf72, chromosome 9 open reading frame 72 expansion; FTD‐ALS, frontotemporal dementia‐amyotrophic lateral sclerosis; GRN, granulin variants; HC, healthy controls; MAPT, microtubule associate protein tau variants; SAA, seeding amplification assay; TARDP, TAR DNA‐binding protein variants; TDP‐43, TAR DNA‐binding protein 43; ThT, thioflavin T