FIGURE 4.

Distribution pattern of TDP‐43 aggregates. Cells obtained by olfactory brushing stained with phosphorylated TDP‐43 (pTDP43, green), p62 (red), and DAPI (blue). A and B, Two representative healthy controls (HC). C, One representative patient with C9orf72 repeat expansion (C9orf72). D, One representative patient with granulin variant (GRN). See Results section for details. Original 40X images (scale bar 25 μM) on the left, with insets on the three right columns. C9orf72, chromosome 9 open reading frame 72 expansion; TDP‐43, TAR DNA‐binding protein 43