TABLE 5.
Signal log ratios (log2 scale) of the genes that are significantly altered after SARS-CoV or HCoV-229E infection
| Category and subcategory | Gene
|
Description | Signal log ratio (log2 scale)a after infection with:
|
||||
|---|---|---|---|---|---|---|---|
| Affymetrix identification no. | Designation | HCoV-229E
|
SARS-CoV
|
||||
| 2 h | 4 h | 2 h | 4 h | ||||
| Apoptosis | |||||||
| Antiapoptosis | 200797_s_at | MCL1 | Myeloid cell leukemia sequence 1 (BCL2 related) | 0.2 | 0 | 1 | 0.3 |
| 210538_s_at | BIRC3 | Baculoviral IAP repeat containing 3 | 0.2 | 0.6 | 2.1 | 1.4 | |
| 201631_s_at | IER3 | Immediate-early response 3 | 0.3 | −0.2 | 1.7 | 1.3 | |
| Apoptosis | 204285_s_at | PMAIP1b | Phorbol-12-myristate-13-acetate-induced protein 1 | 0.5 | −0.2 | 1.6 | 0.6 |
| 204908_s_at | BCL3b | B-cell CLL/lymphoma 3 | 0.1 | 0.1 | 1.9 | 1.1 | |
| 207181_s_at | CASP7 | Caspase 7, apoptosis-related cysteine protease | −0.2 | 0.4 | 0.1 | 1.2 | |
| 208478_s_at | BAX | BCL2-associated X protein | 0.5 | 0.6 | 0.4 | 1.1 | |
| 208536_s_at | BCL2L11 | BCL2-like 11 (apoptosis facilitator) | −1.3 | 0.3 | 0.1 | 1.2 | |
| 209305_s_at | GADD45Bb | Growth arrest and DNA-damage-inducible, beta | 0.1 | −0.2 | 1.4 | 0.8 | |
| 210025_s_at | CARD10b | Caspase recruitment domain family, member 10 | 1 | −0.4 | 1.9 | 2.7 | |
| 211085_s_at | STK4 | Serine/threonine kinase 4 | 0.4 | 1.3 | 0.2 | 0.6 | |
| 211695_x_at | MUC1 | Mucin 1, transmembrane | −0.2 | −1.3 | −0.1 | −0.8 | |
| 218368_s_at | TNFRSF12A | Tumor necrosis factor receptor superfamily, member 12A | 0.5 | 0 | 1 | 0.6 | |
| 218880_at | FOSL2 | FOS-like antigen 2 | 1.8 | −0.4 | 3.3 | 1.5 | |
| 217997_atb | PHLDA1 | Pleckstrin homology-like domain, family A, member 1 | 0.5 | 0.1 | 2.9 | 1.6 | |
| DNA repair | 205022_s_at | CHES1 | Checkpoint suppressor 1 | 0 | −0.2 | 0.2 | −1 |
| 205072_s_at | XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | −1.1 | −0.2 | −1.3 | −0.3 | |
| 208386_x_at | DMC1 | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination | −0.1 | 1.2 | 0.4 | 0.2 | |
| 209579_s_at | MBD4 | Methyl-CpG binding domain protein 4 | 0.1 | 0.6 | 0.2 | 1 | |
| 219317_at | POLI | Polymerase (DNA directed) iota | 0 | 1.1 | −0.6 | 0.5 | |
| Other | 204178_s_at | RBM14 | RNA binding motif protein 14 | −0.3 | 0.5 | −0.3 | 1 |
| 209803_s_at | PHLDA2 | Pleckstrin homology-like domain, family A, member 2 | 0.1 | 0.1 | 0.4 | 1 | |
| 215338_s_at | NKTR | Natural killer-tumor recognition sequence | 0.8 | 1 | 0.3 | 0.2 | |
| Inflammation | |||||||
| Anti-inflammatory | 201502_s_at | NFKBIA/IKBA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha/I-kappa B alpha | 0.2 | −0.1 | 1.4 | 0.5 |
| 221577_x_at | PLAB | Prostate differentiation factor | 0.6 | −0.2 | 1.8 | 0.5 | |
| Proinflammatory | 202510_s_at | TNFAIP2 | Tumor necrosis factor alpha-induced protein 2 | −0.3 | −0.3 | 1.2 | 1.2 |
| 202625_at | LYNb | v-yes-1 Yamaguchi sarcoma viral related oncogene homology/oncogene LYN | 0.1 | −0.1 | −0.2 | 1.2 | |
| 202637_s_at | ICAM1b | Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 0.2 | −0.3 | 2.5 | 1.8 | |
| 202644_s_at | TNFAIP3b | Tumor necrosis factor alpha-induced protein 3 | 0.2 | −0.1 | 2.1 | 1 | |
| 203313_s_at | TGIF | TGFB-induced factor (TALE family homeobox) | 0.5 | 0.3 | 1 | 1 | |
| 203964_at | NMI | N-myc (and STAT) interactor (transcription from Pol II promoter, inflammatory response, JAK-STAT cascade) | 0 | 0.2 | 0.2 | 1 | |
| 204470_at | CXCL1 | Chemokine (C-X-C motif) ligand 1 (melanoma growth-stimulating activity, alpha) | 0.8 | −0.2 | 3.1 | 0.9 | |
| 205114_s_at | CCL3/MIP1A | Chemokine (C-C motif) ligand 3/macrophage inflammatory protein 1-alpha | 0.5 | 0.4 | 1.4 | 1 | |
| 205476_at | CCL20/MIP3A | Chemokine (C-C motif) ligand 20/macrophage inflammatory protein 3-alpha | 0.4 | −0.2 | 1.2 | 0.8 | |
| 205844_at | VNN1 | Vanin 1 | −0.6 | 0.3 | 0.1 | 1.2 | |
| 205922_at | VNN2 | Vanin 2 | 0.7 | −0.2 | 0.8 | 1 | |
| 206336_at | CXCL6 | Chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 0.2 | 0.4 | 0.5 | 1.3 | |
| 207850_at | CXCL3/MIP2B | Chemokine (C-X-C motif) ligand 3/macrophage inflammatory protein 2-beta | 0.2 | 1.6 | 5.2 | 3.5 | |
| 208991_at | STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | 0 | −0.5 | 1 | 0.4 | |
| 209636_at | NFKB2b | Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 | −0.8 | −1.4 | 2.5 | 2.7 | |
| 209774_x_at | CXCL2/MIP2A | Chemokine (C-X-C motif) ligand 2/macrophage inflammatory protein 2-alpha | 1.1 | 0 | 3 | 1.6 | |
| 209909_s_at | TGFB2b | Transforming growth factor beta 2 | 0.1 | 0.2 | 0.9 | 2.1 | |
| 211000_s_at | IL-6STb | Interleukin-6 signal transducer (gp130, oncostatin M receptor) | 0.5 | 0.9 | 0 | 1.3 | |
| 211506_s_at | IL-8b | Interleukin-8 | 0.6 | 0.7 | 3.3 | 2.1 | |
| 212063_at | CD44 | CD44 antigen (homing function and Indian blood group system) | 0.1 | −0.1 | 0.5 | 1.1 | |
| 212989_at | CXCL10 | Chemokine (C-X-C motif) ligand 10 or Mob protein | 0.2 | 0.6 | 0.9 | 1 | |
| 215101_s_at | CXCL5 | Chemokine (C-X-C motif) ligand 5 | −0.2 | 0.4 | 1.6 | 2 | |
| 217738_at | PBEFb | Pre-B-cell colony-enhancing factor | 0 | −0.1 | 1.5 | 1.3 | |
| AFFX- HUMIS GF3A/ M97935 _5_at | ISGF-3 | Interferon-stimulated transcription factor 3 | 0.1 | 0.4 | 0.4 | 1.3 | |
| Immuno- modulatory | 201667_at | GJA1/CX43 | Gap junction protein, alpha 1/gap junction protein 43-KD/connexin 43/heart connexin | 0 | 0.3 | 0.7 | 1.4 |
| 220954_s_at | PILR, BETA | Paired immunoglobulin-like receptor beta | −0.2 | 1 | −0.3 | 0.9 | |
| Other | 202531_at | IRF1 | Interferon regulatory factor 1 | 0.1 | −0.6 | 1 | 0.1 |
| 204622_x_at | NR4A2 | Nuclear receptor subfamily 4, group A, member 2 | 0.3 | −0.3 | −1.6 | −0.9 | |
| 204897_at | PTGER4 | Prostaglandin E receptor 4 (subtype EP4) | 0.2 | 0.2 | 1.2 | 1.1 | |
| 205220_at | Chemokine receptor HM74 | Putative chemokine receptor | 0.2 | −0.1 | 1.7 | 1 | |
| 206785_s_at | KLRC2 | Killer cell lectin-like receptor subfamily C, member 2 | 0.3 | 2.2 | 3.8 | 5.2 | |
| 220491_at | HAMP | Hepcidin antimicrobial peptide | 0.4 | −0.4 | 2.1 | 0.2 | |
| Coagulation | |||||||
| Anticoagulants | 209277_at | TFPI2b | Tissue factor pathway inhibitor 2 | 1 | 0.9 | 2.1 | 3 |
| Procoagulants | 202446_s_at | PLSCR1/MMTRA1B | Phospholipid scramblase 1 | 0 | 0.2 | 0.6 | 1.2 |
| 201110_s_at | THBS1b | Thrombospondin 1 | 0.5 | 0.2 | 2.3 | 1.1 | |
| 201693_s_at | EGR1b | Early growth response 1 | 0.1 | −0.9 | 1 | −1.1 | |
| 202627_s_at | PAI1 | Plasminogen activator inhibitor 1, serpine 1 | −0.4 | −0.6 | 1.3 | 1.8 | |
| Metabolism | |||||||
| Amino acid | 201739_at | SGK | Serum/glucocorticoid regulated kinase | 0.2 | −0.2 | 1 | 0.4 |
| 206669_at | GAD1 | Glutamate decarboxylase 1 (brain, 67 kDa) | 0.1 | 2.9 | 2.8 | 3 | |
| 219795_at | SLC6A14 | Solute carrier family 6 (neurotransmitter transporter), member 14 | −0.1 | 0.4 | 1.1 | 2 | |
| 222018_at | NACA | Nascent-polypeptide-associated complex alpha polypeptide | 0.3 | 1 | −0.4 | 0.4 | |
| Carbohydrate | 202464_s_at | PFKFB3 | 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.1 | 0.3 | 1.1 | 1.1 |
| 214850_at | SMA5 | H. sapiens beta glucuronidase pseudogene | 1 | 1.5 | 0.8 | 2.1 | |
| 215977_x_at | GK | Glycerol kinase | 0 | 0.6 | 0.8 | 1 | |
| 218918_at | MAN1C1 | Mannosidase, alpha, class 1C, member 1 | −0.3 | 0.2 | −0.8 | −1 | |
| 218985_at | SLC2A8 | Solute carrier family 2 (facilitated glucose transporter), member 8 | −0.1 | 0.4 | 0.3 | 1 | |
| 219508_at | GCNT3 | Glucosaminyl (N-acetyl) transferase 3, mucin type | 0.2 | 0.1 | 1 | 1 | |
| 219797_at | MGAT4A | Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A | 0.4 | 0.7 | 0.9 | 1.2 | |
| Lipid | 202067_s_at | LDLRb | Low-density lipoprotein receptor (familial hypercholesterolemia) | 0.5 | −0.3 | 1.5 | −0.3 |
| 204242_s_at | ACOX3 | Acyl coenzyme A oxidase 3, pristanoyl | 0.3 | 0 | 0.5 | 1.3 | |
| 205769_at | SLC27A2 | Solute carrier family 27 (fatty acid transporter), member 2 | 0 | −0.3 | −0.6 | −1.2 | |
| 205822_s_at | HMGCS1 | 3-Hydroxy-3-methylglutaryl coenzyme A synthase 1 (soluble) | 0 | 0.8 | 0.7 | 1 | |
| 212226_s_at | PPAP2Bb | Phosphatidic acid phosphatase type 2B | 0 | −0.3 | 1.2 | −0.3 | |
| Transporters | 202437_s_at | CYP1B1b | Cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.6 | 1.5 | 3 | 3.5 |
| 204685_s_at | ATP2B2 | ATPase, Ca2+ transporting, plasma membrane 2 | 0 | −0.3 | 0.1 | −1 | |
| 205195_at | AP1S1b | Adaptor-related protein complex 1, sigma 1 subunit | 1.7 | 1.7 | 1 | 2.1 | |
| 205749_at | CYP1A1 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | −0.4 | 1.7 | 1.6 | 2.5 | |
| 207604_s_at | SLC4A7b | Solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.3 | 0.6 | 0.7 | 1.4 | |
| 208914_at | GGA2 | Golgi-associated, gamma adaptin ear-containing, ARF binding protein 2 | −0.2 | −0.5 | −0.2 | −1 | |
| 210357_s_at | SMOX | Spermine oxidase | 0 | −0.2 | 1.2 | 1.3 | |
| 211572_s_at | SLC23A1 | Solute carrier family 23 (nucleobase transporters), member 1 | 0.3 | 0.1 | 0 | 1 | |
| 218703_at | SEC22L2 | SEC22 vesicle trafficking protein-like 2 | 1 | 1.3 | −0.5 | 0.9 | |
| 220786_s_at | SLC38A4 | Solute carrier family 38, member 4 | −0.2 | 0 | −0.7 | −1.1 | |
| Miscellaneous | 201556_s_at | VAMP2 | Vesicle-associated membrane protein 2 (synaptobrevin 2) | 0 | −1.8 | −0.7 | −0.8 |
| 202238_s_at | NNMTb | Nicotinamide N-methyltransferase | 0.4 | 0.5 | 1.9 | 2.8 | |
| 203798_s_at | VSNL1 | Visinin-like 1 | −0.1 | −0.1 | 0 | −1 | |
| 206293_at | SULT2A1 | Sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone preferring, member 1 | −0.2 | 0 | −0.3 | −1 | |
| 208776_at | PSMD11 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0 | −0.3 | −0.2 | −1 | |
| 210447_at | GLUD2 | Glutamate dehydrogenase 2 | −0.2 | −0.1 | −0.9 | −1 | |
| 213926_s_at | HRB | HIV-1c Rev binding protein | 0.2 | 0.4 | 0.3 | 1 | |
| 214837_at | ALB | Albumin | −0.2 | 1.2 | −0.7 | 0.2 | |
| 216049_at | RHOBTB3 | Rho-related BTB domain-containing 3 | −0.5 | −0.4 | −1 | −0.6 | |
| Signal transduction | 201010_s_at | TXNIP | Thioredoxin-interacting protein | −0.5 | −0.2 | −1.6 | −0.6 |
| 201044_x_at | DUSP1b | Dual-specificity phosphatase 1 | 0.1 | −0.4 | 3.2 | 2.1 | |
| 201295_s_at | WSB1 | SOCS box-containing WD protein SWiP-1 | 0.2 | 1.6 | −0.2 | 1.4 | |
| 201824_at | RNF14 | Ring finger protein 14 | −0.2 | −0.1 | −1.2 | −0.3 | |
| 203879_at | PIK3CD | Phosphoinositide-3-kinase, catalytic, delta polypeptide | −0.2 | −0.3 | 0.1 | 1.2 | |
| 205205_at | RELB | v-Rel reticuloendotheliosis viral oncogene homolog B, nuclear factor | 0.3 | −0.5 | 1.4 | 0.8 | |
| of kappa light polypeptide gene enhancer in B cells 3 (avian) | |||||||
| 205239_at | AREG | Amphiregulin (schwannoma-derived growth factor) | 0.4 | 0.8 | 1.5 | 0.7 | |
| 205868_s_at | PTPN11 | Protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 0.6 | 1.6 | 0.6 | 0.8 | |
| 210056_at | RHO6 | GTP binding protein | 0.7 | 0.3 | 3.8 | 2.6 | |
| 211962_s_at | ZFP36L1 | Zinc finger protein 36 | 0.2 | 0 | 1.1 | 0.7 | |
| 212099_at | ARHB | Ras homolog gene family, member B | 0.2 | −0.5 | 1.3 | 0.6 | |
| 212777_at | SOS1b | Son of sevenless homolog 1 (Drosophila) | 0 | 0.8 | 0.6 | 1.2 | |
| 213848_at | DUSP7 | Dual-specificity phosphatase 7 | −0.3 | 0.1 | −1 | −0.2 | |
| 213880_at | GPR49 | G protein-coupled receptor 49 | 0.2 | 0.5 | −0.4 | 1.7 | |
| 218295_s_at | NUP50 | Nucleoporin, 50 kDa | 0.2 | 0.8 | 0.4 | 1 | |
| 219677_at | SSB1 | SPRY domain-containing SOCS box protein SSB-1 | 0.4 | 0.2 | 1.4 | 0.6 | |
| 41660_at | CELSR1 | Cadherin epidermal growth factor LAG seven-pass G-type receptor 1 | 0.7 | 0.6 | 0.4 | 1.1 | |
| AFFX-HUM RGE/M10098_ 5_at | GPR34 | G protein-coupled receptor 34 | −2.7 | 3 | 0.9 | 3.7 | |
| Transcription | 201169_s_at | BHLHB2b | Basic helix-loop-helix domain containing, class B, 2 | 0 | 0 | 1.3 | 1.8 |
| 201473_at | JUNB | Jun B proto-oncogene | 0.5 | −0.3 | 2.4 | 2.2 | |
| 201510_atb | ELF3* | E74-like factor 3 (Ets domain transcription factor, epithelial specific) | 0.5 | 0 | 1.9 | 1.3 | |
| 202601_s_at | HTATSF1/TATSF1 | HIV TAT specific factor 1 | 0.7 | 1.4 | 0.9 | 1.1 | |
| 202672_s_at | ATF3 | Activating transcription factor 3 | 0.6 | −0.6 | 2.2 | 0.1 | |
| 202935_s_at | SOX9 | SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex reversal) | 0.4 | −0.3 | 1.1 | −0.3 | |
| 203751_x_at | JUNDb | Jun D proto-oncogene | 0.5 | −1.2 | 1.4 | −0.4 | |
| 203973_s_at | CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 0.6 | −0.6 | 2.3 | 1.5 | |
| 204069_at | MEIS1 | Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) | −1.1 | 0.3 | −0.7 | 0.1 | |
| 205187_at | SMAD5 | Mothers against DPP homolog 5 (Drosophila) SMAD | 0.9 | 1 | 1.3 | 1.4 | |
| 205398_s_at | SMAD3 | SMAD, mothers against DPP homolog 3 (Drosophila) | 0.4 | 0.1 | 1 | 1.1 | |
| 205443_at | SNAPC1 | Small nuclear RNA activating complex, polypeptide 1 | 0.4 | 0.6 | 1 | 0.8 | |
| 205471_s_at | DACH1 | Dachshund homolog (Drosophila) 1 | 0.4 | −0.6 | −0.1 | −1 | |
| 205975_s_at | HOXD1 | Homeo box D1 | 0 | −0.3 | 1 | 0.7 | |
| 206036_s_at | REL | v-Rel reticuloendotheliosis viral oncogene homolog (avian) | 0.4 | 0.2 | 1 | 0.1 | |
| 206175_x_at | ZNF222 | Zinc finger protein 222 | 0.2 | 1 | 0.1 | 0.5 | |
| 207147_at | DLX2 | Distal-less homeo box 2 | 0.7 | −1.8 | 1.5 | 1.7 | |
| 207558_s_at | PITX2 | Paired-like homeodomain transcription factor 2 | −0.2 | 1.1 | −1 | −0.1 | |
| 208129_x_at | RUNX1 | Runt-related transcription factor 1 (acute myeloid leukemia 1; am11 oncogene) | 0.5 | 0.7 | 1 | 0.4 | |
| 209291_at | ID4 | Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.2 | −0.2 | −0.6 | −1 | |
| 209357_atb | CITED2b | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.1 | −0.1 | −1.4 | −0.2 | |
| 209505_at | NR2F1 | Nuclear receptor subfamily 2, group F, member 1 | −0.1 | −0.2 | −1 | −0.3 | |
| 209757_s_at | MYCN | v-Myc myelocytomatosis viral related oncogene, neuroblastoma | 0.2 | −0.3 | −1.1 | −0.7 | |
| derived (avian) | |||||||
| 212641_at | HIVEP2 | HIV-2 1 enhancer-binding protein 2 | 0.3 | −0.1 | 1.8 | 0.2 | |
| 213668_s_at | SOX4b | SRY (sex-determining region Y) box 4 | 0.5 | 0.7 | 1.8 | 1.3 | |
| 213844_at | HOXA5 | Homeo box A5 | −0.1 | 0.1 | 1.1 | 1 | |
| 213906_at | MYBL1 | v-Myb myeloblastosis viral oncogene homolog (avian)-like 1 | −0.5 | 0.4 | −1 | 0.2 | |
| 214639_s_at | HOXA1 | Homeo box A1 | −1.1 | −1.2 | 1.3 | 1.9 | |
| 215073_s_at | NR2F2b | Nuclear receptor subfamily 2, group F, member 2 | 0.1 | 0 | −1.2 | −0.5 | |
| 215720_s_at | NFYA | Nuclear transcription factor Y, alpha | 0.4 | 1.6 | 0.8 | 1.4 | |
| 218559_s_at | MAFB | v-Maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | −0.4 | 0 | −1.4 | −1.3 | |
| 220444_at | ZNF557 | Zinc finger protein 557 | 2.3 | 2.2 | 0.9 | 2.4 | |
| 221773_at | ELK3 | ETS domain protein | −0.3 | 0.1 | −0.1 | 1 | |
| 221883_at | PKNOX1 | PBX/knotted 1 homeobox 1 | 0.8 | 0.9 | 0.2 | 1.7 | |
| 36711_at | MAFFb | v-Maf musculoaponeurotic fibrosarcoma (avian) oncogene family | 0.6 | −1 | 1.9 | 0 | |
| 40837_at | TLE2 | Transducin-like enhancer of split 2 [E(sp1) homolog, Drosophila] | −0.6 | −1 | −0.5 | −0.5 | |
| 44783_s_at | HEY1 | Hairy/enhancer-of-split related with YRPW motif 1 | 0 | 0.3 | 0.6 | 1.3 | |
| Cell cycle | 201055_s_at | HNRPA0 | Heterogeneous nuclear ribonucleoprotein A0 | 0.1 | 0.6 | 0.5 | 1 |
| 202150_s_at | NEDD9 | Neural precursor cell expressed, developmentally downregulated 9 | 0 | −0.8 | 1.1 | 0.8 | |
| 202768_at | FOSB | FBJ murine osteosarcoma viral oncogene homolog B | −0.3 | −0.4 | 3.8 | −0.1 | |
| 202769_at | CCNG2b | Cyclin G2 | 0.1 | 0 | −0.2 | 1.5 | |
| 203120_at | TP53BP2 | Tumor protein p53 binding protein, 2 | 0.3 | 0.2 | 1.1 | 0.4 | |
| 204137_at | TM7SF1 | Transmembrane 7 superfamily member 1 (upregulated in kidney) | 1.7 | 1.6 | 1.3 | 2.7 | |
| 204159_at | CDKN2C | Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | −0.2 | 0.1 | −1.3 | −0.7 | |
| 205027_s_at | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | −0.1 | 0.7 | 1.9 | 0.7 | |
| 205046_at | CENPE | Centromere protein E | 0.1 | 1.1 | −0.1 | 0.8 | |
| 205425_at | HIP1 | Huntingtin-interacting protein 1 | −0.1 | −1 | −0.7 | −0.9 | |
| 207530_s_at | CDKN2B | Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 0.4 | 2.3 | 2.5 | 3.9 | |
| 209680_s_at | KIFC1 | Kinesin family member C1 | 0 | 0.4 | −0.6 | 1 | |
| 210136_at | MBP | Myelin basic protein | 0.4 | 0.5 | 1.1 | 0.9 | |
| 212000_at | SFRS14 | Arginine/serine-rich 14 splicing factor | 0.8 | 1.2 | 0.4 | 0.8 | |
| 212769_at | TLE3 | Transducin-like enhancer of split 3 [E(sp1) homolog, Drosophila] | 0 | 0.2 | 1.2 | 0.7 | |
| 221841_s_at | KLF4 | Kruppel-like factor 4 | 0.4 | −0.8 | 1.3 | 0 | |
| 222303_at | ETS2 | v-Ets avian erythroblastosis virus E26 oncogene homolog 2 | −0.2 | 0.5 | 1.2 | 0.8 | |
| Cell growth and differentiation | 201329_s_at | ETS2b | v-Ets crythroblastosis virus E26 oncogene homolog 2 (avian) | 0.3 | 0.1 | 2 | 1.3 |
| 201341_atb | ENC1/PIG10/NRPB | Ectodermal-neural cortex (with BTB-like domain) p53-induced gene 10; nuclear restricted protein/brain | 0 | 0.2 | 0.8 | 1.2 | |
| 207401_at | PROX1 | Prospero-related homeobox 1 | 0.3 | 0.5 | 1.2 | 1.1 | |
| 210001_s_at | SOCS1 | Suppressor of cytokine signaling 1 | 0.2 | −0.5 | 1.1 | 0.4 | |
| 210587_at | INHBE | Inhibin, beta E | 0.2 | −0.1 | 0.9 | 1.1 | |
| 213004_at | ANGPTL2 | Angiopoietin-like 2 | −0.1 | 0.1 | 0.3 | 1 | |
| 216684_s_at | SS18b | Synovial sarcoma translocation, chromosome 18 | 0.9 | 1.5 | 1.3 | 1.7 | |
| Stress response | 200664_s_at | DNAJB1 | Heat shock 40-kDa protein 1 | 0.1 | 0.4 | 1 | 0.7 |
| 202376_at | AACT/SERPINA3 | Alpha-1 antichymotrpysin/serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | −0.4 | −0.8 | 1.4 | 1.3 | |
| 202581_at | HSPA1B/HSP70-2 | Heat shock 70-kDa protein 1B/heat shock protein, 70 kDa 2 | −0.2 | 0.8 | −0.2 | 1 | |
| 208607_s_at | SAA2 | Serum amyloid A2 | 2.7 | 2 | 3.5 | 3.7 | |
| 209799_at | PRKAA1 | Protein kinase, AMP activated, alpha 1 catalytic subunit | 0 | 0.7 | 0.2 | 1.1 | |
| 215078_at | SOD2b | Superoxide dismutase 2, mitochondrial | 0.4 | 0.4 | 3 | 1.7 | |
| 221477_s_at | SOD7 | Superoxide dismutase 2, mitochondrial | 0 | 0.1 | 1.1 | 1.3 | |
| Miscellaneous | 202241_at | TR1B1 | Tribbles homolog 1 (Drosophila) | −0.1 | −0.6 | 1.1 | 0.3 |
| 202458_at | SPUVE | Protease, serine, 23 | 0.1 | 0.2 | 0.4 | 1 | |
| 202760_s_at | AKAP2 | A kinase (PRKA) anchor protein 2 | 0.6 | 0 | 1.1 | 0.1 | |
| 203234_at | UPP1 | Uridine phosphorylase 1 | −0.6 | 0.3 | 0.3 | 1.3 | |
| 205890_s_at | UBD | Ubiquitin D | 0 | −0.2 | 1.3 | 2 | |
| 206374_at | DUSP8 | Dual-specificity phosphatase 8 | 0.6 | −0.6 | 1.7 | −0.7 | |
| 210159_s_at | TRIM31b | Tripartite motif-containing 31 | 2.2 | 1.1 | 2.3 | 3 | |
| 212027_at | RBM25 | RNA binding motif protein 25 | 0.2 | 1.1 | 0.3 | 0.9 | |
| 212244_at | GRINL1A | Glutamate receptor, ionotropic, N-methyl d-aspartate-like 1A | −0.2 | −0.1 | −1 | −0.2 | |
| 212905_at | CSTF2T | Cleavage stimulation factor, 3′ pre-RNA, subunit 2, 64 kDa, tau variant | −0.5 | 0 | −1.1 | 0.1 | |
| 213006_at | KIAA0146 | KIAA0146 protein | 0.2 | −0.6 | 1.8 | 1.1 | |
| 217475_s_at | LIMK2 | LIM domain kinase 2 | 0.2 | 0.3 | 1 | 0.5 | |
| 218737_at | SBNO1 | Sno, strawberry notch homolog 1 | 0.9 | 1 | 0.3 | 1 | |
| 218810_at | FLJ23231 | Hypothetical protein FLJ23231 | −1 | −3.5 | 2.7 | 1.3 | |
| 220992_s_at | C1orf25 | Chromosome 1 open reading frame 25 | 0.1 | 1.2 | −0.1 | 1 | |
| 221258_s_at | DKFZP434G2226 | Kinesin family member 18A | 0 | 0.6 | −0.9 | 1 | |
| Unknown functions | 204447_at | ProSAPiP1 | ProSAPiP1 protein | 0.1 | −0.8 | 0 | −1.2 |
| 204492_at | ARHGAP11A | KIAA0013 gene product | 0.5 | 1 | −0.2 | 0.5 | |
| 208154_at | LOC51336 | Mesenchymal stem cell protein DSCD28 | −0.7 | −0.3 | −0.1 | −1.2 | |
| 212686_at | PPM1H | Protein phosphatase 1H (PP2C domain containing) | 0 | −0.4 | −0.1 | −1.1 | |
| 212845_at | SAMD4 | Sterile alpha motif domain containing 4 | 0.1 | −0.4 | 1 | −0.5 | |
| 213069_at | HEGb | HEG homolog | 0.3 | −0.3 | 1.1 | −0.2 | |
| 213256_at | MGC48332 | Hypothetical protein MGC48332 | 0 | 0.2 | 0.4 | 1.1 | |
| 214077_x_at | MEIS3 | Meis1, myeloid ecotropic viral integration site 1 homolog 3 (mouse) | 0.5 | 0.4 | 0.3 | 1.2 | |
| 214862_x_at | MRNA; cDNA DKFZp564G1162 | −0.1 | −0.1 | −1 | −0.6 | ||
| 215281_x_at | POGZ | Pogo transposable element with ZNF domain | 0 | 1 | 0.1 | −0.3 | |
| 216715_at | 1.2 | 1.3 | 1 | 1.1 | |||
| 217047_s_at | FAM13A1b | Family with sequence similarity 13, member A1 | −0.3 | 0.6 | −1 | −0.1 | |
| 217300_at | −1 | −0.2 | −1 | −0.4 | |||
| 218031_s_at | C14orf116 | Chromosome 14 open reading frame 116 | 0.1 | −0.7 | 0.2 | −1 | |
| 218541_s_at | C8orf4 | Chromosome 8 open reading frame 4 | 0.4 | 0.1 | 1.3 | 0.9 | |
| 218816_at | LANO | LAP (leucine-rich repeats and PDZ) and no PDZ protein | 0.1 | 0.3 | 0 | 1 | |
| 219010_at | FLJ10901 | Hypothetical protein FLJ10901 | −0.1 | 0.1 | 1 | 1.6 | |
| 219166_at | C14orf104 | Chromosome 14 open reading frame 104 | −0.4 | 0.3 | −1.3 | 0.4 | |
| 219696_at | FLJ20054 | Hypothetical protein FLJ20054 | 0.1 | −0.1 | −0.2 | −1 | |
| 220041_at | SMP3 | SMP3 mannosyltransferase | −0.4 | −1.1 | −0.5 | −1 | |
| 220441_at | FLJ13236 | Hypothetical protein FLJ13236 | 0 | 0.4 | 0.5 | 1.4 | |
| 220770_s_at | LOC63920 | Transposon-derived Buster3 transposase-like | −0.6 | 1.3 | −0.8 | 1 | |
| 222196_at | LOC286434 | Hypothetical protein LOC286434 | 1.1 | 0.8 | 0.9 | 2.2 | |
| AFFX-r2-Hs18Sr RNA-M_x_at | Human 18S rRNAb | −2.1 | 1.7 | 0.7 | 2.6 | ||
| AFFX-r2- | Human 28S rRNAb | −1.4 | 0.7 | 0.5 | 1.2 | ||
| Hs28Sr RNA-3_at | |||||||
Minus, decreased gene expression; no minus, increased gene expression; underlining, two-to fourfold-increased or decreased gene expression; boldface, >4-fold-increased or decreased gene expression.
More than one probe set has a significant change in gene expression; only the most representative is shown.
HIV-1, human immunodeficiency virus type 1.