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Cellular immunity elicited by DNA prime and ADV5 boost immunizations is mediated by both CD4+ and CD8+ T lymphocytes. Freshly isolated PBMC from two cohorts of immunized monkeys (A and B) were depleted of CD8+ T lymphocytes. IFN-γ ELISPOT responses were measured in unfractionated as well as CD8+ T-cell-depleted PBMC of the monkeys 2 weeks following the final ADV5 immunizations.
