Table 1.
The clinical details of four patients infected with Candida auris.
| Case 1 | Case 2 | Case 3 | Case 4 | |
|---|---|---|---|---|
| Age/Sex | 59/Male | 67/Male | 73/Male | 64/Male |
| Duration of hospitalisation (days) | 37 | 27 | 23 | 73 |
| Previous admission to a lower-level hospital | Yes | Yes | Yes | Yes |
| Surgery within 30 days or during hospitalisation | Tracheostomy | Tracheostomy | No | Tracheostomy |
| ICU admission | No | Yes | Yes | Yes |
| Parenteral nutrition | Yes | Yes | Yes | Yes |
| Corticosteroid during hospitalisation | Yes | Yes | Yes | Yes |
| Underlying lung disease | Respiratory failure Pneumonia Post COVID-19 |
Respiratory failure Pneumonia COPD History of TB Bronchiectasis |
Respiratory failure Pneumonia COPD |
Respiratory failure Pneumonia COPD |
| Underlying cardiac disease | Hypertension | Hypertension | Ischaemic heart disease Pulmonary embolism |
No |
| Underlying liver disease | No | No | No | Acute hepatitis B |
| Other underlying condition | Myelodysplastic syndromes Neutropenia Malnutrition Hypoalbuminaemia |
Functional bowel obstruction Septic shock Cushing syndrome Hypoalbuminaemia |
Acute kidney failure Cushing syndrome Hypoalbuminaemia |
Acute kidney failure Malnutrition Cushing syndrome Hypoalbuminaemia |
| Central venous catheter | No | Yes | Yes | No |
| Endotracheal tube | No | Yes | Yes | Yes |
| Gastric tube | Yes | Yes | No | Yes |
| Urinary catheter | Yes | Yes | No | No |
| Time from admission to positive culture results for C. auris (days) | 22 | 31 | 25 | 10 |
| Specimen positive for C. auris | Blood | Blood | Urine | Sputum, stool |
| C. auris antifungal susceptibility testing (MIC, μg/ml) | ||||
| Fluconazole Caspofungin Amphotericin B | 4 (S) 0.5 (S) 0.25 (S) |
1 (S) 0.06 (S) 32 (R) |
1 (S) 0.25 (S) 0.06 (S) |
2 (S) 0.25 (S) 0.5 (S) |
| Antifungal use before the isolation of C. auris | No | Fluconazole Amphotericin B |
No | No |
| Antifungal treatment after C. auris isolation | Caspofungin | Discharge before obtaining the result | Discharge before obtaining the result | Caspofungin |
| Other pathogen/specimen |
P. aeruginosa (sputum) C. albicans (sputum) |
C. tropicalis (urine) P. aeruginosa (sputum) C. tropicalis (sputum) Strongyloides stercoralis (stool) |
No |
K. pneumonia (sputum) A. baumannii (sputum) C. glabrata (stool) |
| Outcome | Survived | Died | Died | Survived |
Abbreviations: ICU, intensive care unit; COPD, chronic obstructive pulmonary disease; TB, tuberculosis; MIC, minimum inhibitory concentration; S, susceptible; R, resistant.