Figure 8. Graphical model depicting the consequences of SAS-6 loss in mouse embryos, mouse embryonic stem cells (mESCs), and neural progenitor cells (NPCs).

Compared to mouse embryos and in vitro differentiated NPCs, mESCs exhibit a higher concentration of centrosomal components and a robust Polo-Like Kinase 4 (PLK4) activity, as indicated by changes in pericentriolar material color and size. This difference permits the formation of abnormal centrioles in Sass6^−/− mESCs, while it results in the loss of centrioles in developing mouse embryos and NPCs.