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The P-TEFb kinase complex is differentially recruited to and utilized by the IL-8 and IκBα genes in A549 cells. ChIP assays using polyclonal antibodies to Cdk9 (A) or Cyclin T1 (B) were performed on A549 cells treated with combinations of TNF and dex as indicated for 2 h. The immunoprecipitates were probed using qRT–PCR for regions of the IL-8 and IκBα promoter and downstream regions as indicated. The fold enrichment data were normalized to a HSP70 control genomic region.
