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. 2024 Apr 1;15(2):640–697. doi: 10.14336/AD.2023.0520

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Copyright: © 2024 Chan et al.

this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — The roles of MYC act in mediating cell death pathways and their mechanisms. APAF-1: Apoptotic Protease Activating Factor-1, ARF: ADP ribosylation factor; ATG7: Autophagy Related 7; Bcl-2: B-cell lymphoma 2 protein; Bcl-XL: B-cell lymphoma-extra large; BID: BH3 interacting-domain death agonist; c-FlIP: Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein; Cys: Cysteine; DIABLO: Direct Inhibitor of Apoptosis-Binding protein with LOw pI; EGLN1: Egl-9 Family Hypoxia Inducible Factor 1; ER stress: Endoplasmic Reticulum Stress; FADD: Fas Associated Via Death Domain; G4-stabilizer: G4-quadruplex-stabilizer; Glu: Glutamic acid; GPX4: Glutathione peroxidase 4; GSH: glutathione; HIF-1α: Hypoxia Inducible Factor 1 Subunit Alpha; LC3: Microtubule-associated protein 1A/1B-light chain 3; LSH: lymphoid-specific helicase; Mcl-1: Myeloid cell leukemia 1; MDM2: murine double minute 2 homolog; Met: Methionine; PLK: Polo Like Kinase 1; PUMA: p53 upregulated modulator of apoptosis; RIP: Receptor-interacting protein; ROS: reactive oxygen species; Ser62: Serine62; Smac: Second mitochondria-derived activator of caspase; SQSTM1 : sequestosome 1; tBID: truncated BH3 interacting-domain death agonist; Thr58: Threonine58; WDR76: WD Repeat Domain 76; XIAP: X-Linked Inhibitor of Apoptosis.