Table 1.

Effects of promoting or inhibiting mitophagy on RGC in models of glaucoma.

Organism	Model	Assay Conditions	Effects in glaucoma	Reference
Mouse	Microbead model that elevates IOP	Mitochondrial UCP2 knock-out	↑Mitophagy ↓Oxidative stress ↓RGC loss	[115]
Rat	Chronic model induced by translimbal laser photocoagulation of the TM	Overexpression of OPA1	↓RGC cytotoxicity and apoptosis ↑Mitochondria fusion and mitophagy ↑RGC survival	[116]
Rat	Chronic model induced by translimbal laser photocoagulation of the TM	Overexpression of PARKIN	↓RGC loss ↓GFAP expression ↑Optineurin expression ↑Mitochondrial health and partially restored dysfunction of mitophagy	[117]
Mouse	OPTN E50K mutant mouse model	OPTN E50K knock in	↑the Bax pathway and oxidative stress ↓Mitochondria ↑Autophagosome formation ↑Autophagy-lysosome pathway dysfunction	[120, 121]

UCP2, Uncoupling Protein 2; OPA1, Optic Atrophy Type 1; PARKIN, Parkin RBR E3 ubiquitin-protein ligase; IOP, intraocular pressure; RGC, Retinal ganglion cell; GFAP, Glial fibrillary acidic protein; TM, Trabecular meshwork; OPTN, Optineurin.