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In vivo biodistribution of TPH/CH MN applied in CIA mice. (A) IVIS fluorescent images of normal mice and CIA mice treated by TOTO-3 labeled TPH/CH MN at 3 and 6 h. (B) Fluorescence images of the major organs collected from normal and CIA mice after TOTO-3 labeled TPH/CH MN application post 6 h. (C) Quantitative fluorescence analysis for the major organs and paws. Data are shown as the mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001.
