Fig. 6.

Inhibitory effect of TPH/CH MN on arthritic progression in CIA mice. (A) Schematic illustration of the treatment for CIA mice by TPH/CH MN. (B) Representative hind paw images in normal, saline, TPH/CH NCs, TPH MN, CH MN and TPH/CH MN groups at day 30 and day 48. (C) Body weight change vs time in different groups. (D) Paw thickness of mice in normal, saline, TPH/CH NCs, TPH MN, CH MN and TPH/CH MN groups. (E) Clinical scores of mice at the end of the therapy. (F) Micro-CT analysis of the hind paw of mice after treatments. Data are shown as the mean ± SD (n = 6, *p < 0.05, **p < 0.01, and ***p < 0.001).