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. 2024 Jan 24;27(3):433–448. doi: 10.1038/s41593-023-01558-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Of the 3624 detected protein hits from the TMT-based proteomics analysis (see Fig. 4), 2665 were unambiguously mapped to unique Entrez gene IDs. Using the GO term biological process, bar charts depict the GO annotation and functional categorization of identified proteins. WebGestalt.org provided the summary. b, Protein abundance of Kir4.1 (gene Kcnj10) is reduced in samples from cKO (n = 4 mice) compared to ctrl (n = 4, p = 0.0015, moderated t-test). c, Abundance of MCT1 (Slc16a1) is reduced in cKO compared to ctrl (n = 4, p = 0.0004, moderated t-test). d, Abundance of GLUT1 (Slc2a1) is reduced in cKO compared to ctrl (n = 4, p = 0.0308, moderated t-test). e, Abundance of GLUT3 (Slc2a3) is unchanged between genotypes (n = 4, p = 0.2470, moderated t-test). Boxplots with all points show median (line), quartiles (box bounds), and min to max (whiskers). f, Relative mRNA abundance in optic nerve lysates of 3-months-old cKO (n = 5) and littermate ctrls (n = 5): Compared to ctrl, Kir4.1 mRNA levels were reduced by 0.42 ± 0.09 (p = 0.0013, two-sided Student’s t-test) and GLUT1 mRNA levels were reduced by 0.19 ± 0.07 (p = 0.0349, two-sided Student’s t-test). No significant differences in mRNA levels of MCT1 (p = 0.4635) and GLUT3 (p = 0.9690). Data represented as dot-plots with means ± SEM.