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. 2024 Jan 24;27(3):433–448. doi: 10.1038/s41593-023-01558-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a, AAV-mediated glucose FRET sensor FLIIP expression in optic nerve OLs of wildtype mice. Depicted are representative color-coded ratio images from optic nerve in ACSF containing 10 mM glucose (Glc), after removal of extracellular Glc, and following inhibition of glycolysis by 1 mM iodoacetate (IA) in ACSF containing 10 mM Glc. Warm and cold colors indicate high and low ratios or glucose levels, respectively. Scalebar 20 µm. b, Quantification of normalized ratios obtained from conditions presented in a. Ratios (n = 3 mice) were normalized to the averaged minimum obtained at 0 mM [Glc]_O. Data shown in mean ± SEM.