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. 2024 Mar 6;15:2020. doi: 10.1038/s41467-024-46347-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Volcano plot analysis of differentially expressed genes between 19 podoconiosis patient and 15 healthy control samples. The log2-fold change values are plotted on the x axis and compared with the negative log10 P values on the y axis. Blue dots represent significantly downregulated genes, and red dots represent significantly upregulated genes in podoconiosis patients compared with healthy controls with a fold change of >1.5 and P < 0.05. The F test was used for deriving P values and adjustments were made for multiple comparison. Source data that is used to generate this graph is provided as “Source Data” file Figs. 4 and 5.