Table 1.
List of significantly upregulated genes from the top enriched clusters based on their gene ontology category, in peripheral blood from 19 podoconiosis patients and 15 healthy controls
| GO category | Upregulated gene | Gene description | Fc Podo vs HC | P value |
|---|---|---|---|---|
| Immune response | CD1A | CD1a molecule | 1.7 | 0.03 |
| CD80 | CD80 molecule | 1.2 | 0.07 | |
| CD86 | CD86 molecule | 1.3 | 0.06 | |
| HLA-DQB1 | HLA-DQ beta molecule | 1.8 | 0.3 | |
| WAKMAR | Wound and keratinocyte-associated lnRNA | 1.57 | 0.028 | |
| Cell membrane and signaling | OLR1 | Oxidized low-density lipoprotein | 1.74 | 0.03 |
| CD163L1 | CD163-like molecule 1 | 1.57 | 0.02 | |
| MSR1 | Macrophage scavenger receptor 1 | 1.6 | 0.05 | |
| ADIPOR1 | Adiponectin receptor | 1.54 | 0.04 | |
| Cell projection | ITGA1 | Integrin subunit alpha 1 | 1.3 | 0.04 |
| FFAR4 | Free fatty acid receptor 4 | 1.6 | 0.03 | |
| Extracellular region | CTSB | Cathepsin B | 1.7 | 0.01 |
| MPO | Myeloperoxidase | 1.7 | 0.04 | |
| EREG | Epiregulin | 2.5 | 0.006 | |
| BNIP3L | BCL2 interacting protein 3 like | 1.57 | 0.04 |
GO gene ontology, Fc fold change, HC healthy controls, vs versus.
Gene names are italicized.