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. 2024 Mar 6;15:2020. doi: 10.1038/s41467-024-46347-z

Table 2.

List of significantly downregulated genes from the top enriched clusters based on their gene ontology category, in peripheral blood from 19 podoconiosis patients and 15 healthy controls

GO category Downregulated gene Gene description Fc Podo vs HC P value
Histones H3C12 H3 clustered histone 12 3.1 0.0002
H2AC12 H2A clustered histone 12 3 0.0002
H2BC14 H2B clustered histone 14 2.8 0.001
H3C8 H3 clustered histone 8 3.1 0.0002
Cell division cycle CDC6 Cell division cycle 6 2.3 0.0001
CDCA5 Cell division associated 5 2.6 0.003
Immunoglobulin domain IGLV3–21 Immunoglobulin lambda variable 3–21 4.9 0.005
IGLV1–47 Immunoglobulin lambda variable 1–47 3.5 0.007
IGLC3 Immunoglobulin lambda constant 3 3 0.006
IGLC2 Immunoglobulin lambda constant 2 2 0.03
T-cell receptor TRAV26-1 T-cell receptor alpha variable 26-1 1.57 0.03
TRAV10 T-cell receptor alpha variable 10 1.74 0.04
TRBC1 T-cell receptor beta constant 1 1.75 0.03

GO gene ontology, Fc fold change, HC healthy controls, vs versus.

Gene names are italicized.