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. 2024 Mar 6;15:2054. doi: 10.1038/s41467-024-46310-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Representative curves of relative phagocytosis index (RPI) of CD38^low MM cells (KMS-12-BM) induced by ISB 1442 (enhanced Fc) or its respective WT or silenced Fc variants. Dots represent the mean ± SD of n = 2 of technical replicates. B Cumulative data of RPI as in (A). Bars represent mean values of phagocytosis ± SD for 6 donors measured at 0.008 nM (close to the EC50; visualized by an arrow in A). C Representative curves of CDC on CD38^high (Daudi) tumor cells. Dots represent the mean ± SD of n = 2 of technical replicates. D Cumulative data of CDC as in (C). Bars represent the mean of maximal killing ± SD in 6 independent experiments. E Schematic view of ISB 1442 or its dummy controls. Gray Fabs represent the dummy binders (DU). F–M ADCP and CDC induced by ISB 1442 or its dummy controls. F–H Representative curves of RPI on CD38^low MM cells (KMS-12-BM). Dots represent the mean ± SD of n = 2 of technical replicates. G–I Cumulative data of EC50 of phagocytosis as in (F–H). Bars represent mean values of RPI ± SD for 3 donors. J–L Representative curves of CDC on CD38^high (Daudi) tumor cells. K–M Cumulative data of EC50 of phagocytosis of CDC as in J–L Bars represent mean values of maximal killing ± SD in 4 independent experiments. Statistics for (B–D–G–I–K–M): One-Way Anova with Tukey’s multi comparison test, with a single pooled variance. Ns not significant, *p < 0.05, ***p < 0.001, ****p < 0.0001, ****p < 0.0001.