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. 2024 Mar 6;15:2054. doi: 10.1038/s41467-024-46310-y

Fig. 6. On-target off-tumor on RBCs.

Fig. 6

A Means of the binding of ISB 1442 and hu5F9 on human fresh RBCs from 6 independent donors at increasing concentrations. Each dot represents a biological replicate (±SD). Statistics: *p < 0.05 **p < 0.01 ***p < 0.001 ****p < 0.0001 (RM 2-ways Anova). B RBCs quantification using hematology analyzer. Dose-response of RBCs depletion (in %) as a function of ISB 1442 or hu5F9 concentrations with 6 independent human fresh peripheral blood donors. Statistics: *p < 0.05 **p < 0.01 ***p < 0.001 ****p < 0.0001 (RM 2-ways Anova). C Indirect antiglobulin Coombs test. Dose–response of the indirect Coombs score as a function of ISB 1442 or hu5F9 concentrations with 6 independent human fresh peripheral blood donors. D Scatter dot plot showing mean ± SD of EC50 of coombs score as in (C). Each dot represents a biological replicate. Statistics: One-Way Anova with Tukey’s multi comparison test. ****p < 0.0001.