Table 1.
Comparison of viral, bacterial, and fungal targets detected in QS-ME and the concordance with the LDT, IS-pro, culture, and/or Cryptococcus Ag test results
| QS-ME target | LDT, IS-pro, culture, and/or Cryptococcus Ag positive | QS-ME positive | Concordance |
|---|---|---|---|
| Enterovirus | 24 | 24 | 100% |
| HHV-6 | 3 | 3 | 100% |
| HSV-1 | 6 | 6 | 100% |
| HSV-2 | 4 | 4 | 100% |
| Parechovirus | 5 | 5 | 100% |
| VZV | 11 | 12 | 92% |
| E. coli K1 | 1 | 1 | 100% |
| H. influenzae | 7 | 7 | 100% |
| L. monocytogenes | 7 | 6 | 86% |
| M. pneumoniaea | - | - | - |
| N. meningitidis | 10 | 10 | 100% |
| S. agalactiae | 1 | 1 | 100% |
| S. pneumoniae | 11 | 10 | 91% |
| S. pyogenes | 3 | 3 | 100% |
| C. neoformans | 13 | 7 | 54%b |
aThe QS-ME M. pneumoniae target could not be evaluated in this study as there were no M. pneumoniae CSF-positive samples available
bThe concordance between Cryptococcus culture and QS-ME was 50% (2/4) and for CrAg and QS-ME 56% (5/9)