Table 2.
Catchment process, clinical features, laboratory values, and E. coli culture results of 4 identified patients with IED
| IED event catchment details | Signs and symptoms of UTI | Culture result | Signs and symptoms of IED | SIRS | qSOFA | SOFAa |
|---|---|---|---|---|---|---|
| IED event 1 (France) | NA |
• Fever • General symptoms (malaise, fatigue, muscle pain, chills) • Abnormal MAP (mm Hg) • Laboratory values indicating bacterial infection and/or inflammationb |
1 | 0 | 1 | |
| Catchment process: GP contacted LRT (GP was informed via hospital discharge letter) | Blood E. coli isolate | |||||
| IED event 2 (France) | NA |
• Fever • Tachycardia (heart rate > 90 bpm) • General symptoms (malaise, fatigue, muscle pain, chills) • Nausea and/or vomiting • Abnormal MAP (mm Hg) • Laboratory values indicating bacterial infection and/or inflammationb |
2 | 0 | 1 | |
| Catchment process: Participant informed EXPECT-2 PI that he also participates in EXPECT-1 | Blood E. coli isolate | |||||
| IED event 3 (Italy) |
• Dysuria • Flank pain |
• Tachypnoea (respiratory rate > 20 breaths per minute) • Leukocytosis (WBC ≥ 12 × 109/L) • Abnormal MAP (mm Hg) • Laboratory values indicating bacterial infection and/or inflammationb |
2 | 1 | 1 | |
| Catchment process: Participant informed physician in hospital about participation in EXPECT-1 | Blood E. coli isolate | |||||
| IED event 4 (Italy) | • Flank pain |
• Leukocytosis (WBC ≥ 12 × 109/L) • Laboratory values indicating bacterial infection and/or inflammationb |
1 | 0 | 0 | |
| Catchment process: On the follow-up call on day 240, the LRT was informed by the participant that she had been admitted for IED | Blood E. coli isolate |
aWhen no prior SOFA score was available, the change in total score of ≥ 2 was calculated assuming the baseline SOFA score of 0
bIncludes elevated C-reactive protein level and erythrocyte sedimentation rate
bpm beats per minute, EXPECT-2 a second in the series of COMBACTE-NET studies to collect information about IED (ClinicalTrials.gov identifier: NCT04117113), GP general practitioner, IED invasive Escherichia coli disease, LRT local research team, MAP mean arterial pressure, PI principal investigator, qSOFA quick sequential organ failure assessment, SIRS systemic inflammatory response syndrome, SOFA sequential organ failure assessment, UTI urinary tract infection, WBC white blood cell