Figure 8.

Evaluating B2M status at baseline in addition to T-cell infiltration improves the accuracy of predictive scoring for responders. We evaluated the value of testing for B2M status at baseline in addition to either CD8 density or PDL1 staining on baseline tumor biopsies, by fitting a logistic regression on all evaluable patients in our dataset (10-15 responders and 121-150 non-responders, depending on the combination of markers, responders defined as RECIST 1.1 partial or complete response). The plots show the comparison of the sensitivity versus specificity of the single predictor models (A) and each pairwise combination of B2M, PDL1 TC and CD8 density (B). The dotted line visualizes random chance, the round dot in each curve indicates the point of optimal accuracy for each model (Youden’s index).