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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Mol Psychiatry. 2023 Sep 7;28(11):4766–4776. doi: 10.1038/s41380-023-02236-3

Fig 4. Proteins that separate control and AUD cases.

Fig 4.

A Separation of control and AUD cases. B Top 50 loading coefficients for the first component of the sPLS-DA model. Bar length indicated importance of each protein to the model. C Gene ontology enrichment analysis for positive and negative loading coefficients of proteins that separate control and AUD cases. D Bioinformatics analysis linking AP2A1 to alcohol-related behaviors in mouse, monkey, and human. E Cortical expression of Ap2a1 correlated with alcohol drinking in 23 control and alcohol dependent BXD strains. F The B allele at Ap2a1 increased alcohol drinking in 44 BXD strains.