Supplementary Table 6. Multivariable Cox proportional hazard analyses for development of IHD in quartiles of non-HDL-C.
| Unadjusted | Adjusted | |||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Quartiles of non-HDL-C (mg/dL) | ||||
| Q1 (~115), n= 4,094 | Reference | - | Reference | - |
| Q2 (116~138), n= 4,370 | 1.40 (1.06-1.85) | 0.016 | 0.98 (0.75-1.30) | 0.907 |
| Q3 (139~163), n= 4,797 | 1.68 (1.29-2.18) | ＜0.001 | 1.02 (0.78-1.33) | 0.890 |
| Q4 (164~), n= 4,915 | 2.09 (1.62-2.69) | ＜0.001 | 1.17 (0.91-1.52) | 0.226 |
| Age | - | - | 1.07 (1.06-1.08) | ＜0.001 |
| Sex | - | - | 166 (1.34-2.05) | ＜0.001 |
| Obesity＊ | - | - | 1.48 (1.25-1.76) | ＜0.001 |
| Smoking habit | - | - | 1.20 (1.01-1.43) | 0.045 |
| Family history of IHD | - | - | 1.59 (1.26-2.01) | ＜0.001 |
| eGFR | - | - | 0.99 (0.99-1.01) | 0.899 |
| Hypertension | - | - | 1.55 (1.28-1.86) | ＜0.001 |
| Diabetes mellitus | - | - | 1.93 (1.49-2.48) | ＜0.001 |
| (AIC= 10,838) | (AIC= 10,420) | |||
| Interaction [Sex-Quartiles of non-HDL-C] | - | 0.773 | ||
＊Body mass index ≥ 25.
AIC, Akaike's information criterion; CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio; IHD, ischemic heart disease; non-HDL-C, non-high-density lipoprotein cholesterol.