Fig. 1.

Mature mRNA needs N6-methyladenosine (m⁶A) methylation to transfer from the nucleus to the cytoplasm.RNA methylation process and mutation characteristics of m⁶A regulators in lung squamous cell carcinoma (LUSC). A Three different types of m⁶A regulators (readers, erasers and writers) cooperate to mediate the dynamic and reversible RNA methylation process. The ellipses represent different kinds of m⁶A regulators. B The mutation characteristics of 23 m⁶A regulators in the TCGA-LUSC cohort. The left side of the plot shows the names of the m⁶A regulators, the color change in the middle of the waterfall plot indicates the mutation of the corresponding regulator, and the right side of the plot shows the mutation frequency of the regulators. The different colors in the middle of the waterfall plot indicate that the patient has the corresponding somatic mutation type. The bottom heatmap shows changes in single nucleotides in 491 samples. C The copy number variation (CNV) features of the m⁶A regulators of the TCGA-LUSC cohort. D The chromosomal location of the m⁶A regulator CNVs. Red indicates copy number gain, and blue indicates copy number loss. E The difference in the expression of m⁶A regulators between tumor tissues and normal tissues. The upper and lower ends of the box represent the quartile, the horizontal line in the box represents the median, the point outside the box represents the abnormal value, the upper * p < 0.05, * *p < 0.01, * * *p < 0.001.