Figure 5.
Stratified survival analysis of the 22-gene risk score model
Kaplan-Meier survival analysis for the patients in independent datasets by the 22-gene risk score model.
(A) Development of a TRM risk score for GLIOMA by LASSO Cox regression analysis.
(B) Hazard ratios of univariate Cox regression models evaluating the association between overall survival and the 22 genes.
(C) Patients in the TCGA-SKCM, GSE65904, and GSE8401 cohorts.
(D) Forest plot of hazard ratios derived from multivariable Cox regression analysis including the listed variables. The y axis is the risk group (High vs. Low risk), age (>50 vs. ≤ 50), gender (Male vs. Female), tumor stages (High vs. Low stage), and TNM cancer staging (High vs. Low stages of T, N, and M, respectively) of melanoma patients. For the TNM cancer staging system, TNM stands for Tumor, Nodes, and Metastasis. T is assigned based on the extent of involvement at the primary tumor site, N reflects the extent of involvement in regional lymph nodes, and M indicates for distant spread.
(E) Time-dependent of the TCGA-SKCM.