Table 2.
Coagulation parameters at presentation with active disease and at follow-up after 6 months of treatment in patients with active ANCA–associated vasculitis
| Normal range | N | Baseline (IQR) | N | Follow-up (IQR) | Absolute difference (95% CI) | Overall P value | |
|---|---|---|---|---|---|---|---|
| D-dimers, μg/mL | <0.5∗ | 69 | 1.3 (0.6-2.6) | 52 | 0.6 (0.3-1.0) | 0.7 (0.3-1.1) | .017† |
| High D-dimers (%) | 50 (73) | 23 (44) | - | .035† | |||
| Fibrinogen, g/L | 1.7-4.0 | 69 | 6.3 (5.2-8.6) | 52 | 4.9 (3.7-5.7) | 1.4 (0.7-2.7) | <.001† |
| High fibrinogen (%) | 63 (91) | 36 (69) | - | .012† | |||
| PT, s | 10-12 | 69 | 8.7 (8.3-9.3) | 52 | 8.3 (8.2-8.9) | 0.4 (0.0-0.6) | .006† |
| Prolonged PT (%) | 4 (6) | 1 (2) | - | .625 | |||
| APTT, s | 28-32 | 69 | 27 (25-29) | 52 | 26 (24-29) | 0.7 (−0.8 to 2.3) | .040† |
| Prolonged APTT (%) | 5 (7) | 3 (6) | - | .687 | |||
| FVIIa:AT, pM | ≤2641 | 69 | 770 (480-906) | 52 | 664 (399-863) | 106 (−125 to 302) | .174 |
| High FVIIa:AT (%) | 7 (10) | 0 (0) | - | .125 | |||
| FXIIa:AT, pM | ≤118 | 70 | 59 (36-80) | 51 | 47 (32-67) | 11 (−7 to 21) | .401 |
| High FXIIa:AT (%) | 11 (16) | 4 (8) | - | 1.000 | |||
| FXIIa:C1Inh, pM | ≤2166 | 70 | 3889 (3595-4286) | 51 | 3894 (3502-4163) | 6 (−202 to 298) | .162 |
| High FXIIa:C1Inh (%) | 70 (100) | 49 (96) | - | .500 | |||
| FXIa:AT, pM | ≤43 | 69 | 47 (25-94) | 52 | 51 (23-82) | 4 (−31 to 29) | .629 |
| High FXIa:AT (%) | 38 (55) | 29 (56) | - | .687 | |||
| FXIa:α1AT, pM | ≤29 | 69 | 26 (16-39) | 52 | 14 (0.4-22) | 11 (5-19) | <.001† |
| High FXIa:α1AT (%) | 29 (42) | 4 (8) | - | .004† | |||
| FXIa:C1Inh, pM | ≤514 | 69 | 71 (71-235) | 52 | 71 (71-71) | 0 (0-0) | .048† |
| High FXIa:C1Inh (%) | 12 (17) | 2 (4) | - | .125 | |||
| FIXa:AT, pM | ≤472 | 69 | 259 (197-363) | 52 | 246 (187-337) | 13 (−22 to 79) | .376 |
| High FIXa:AT (%) | 11 (16) | 6 (12) | - | 1.000 | |||
| FXa:AT, pM | ≤279 | 69 | 177 (158-206) | 52 | 190 (162-211) | 14 (−826 to 26) | .685 |
| High FXa:AT (%) | 8 (12) | 1 (2) | - | .125 | |||
| T:AT, μg/L | ≤4.7 | 69 | 2.9 (1.8-6.0) | 52 | 2.0 (1.5-2.8) | 0.9 (0.0-1.7) | .009† |
| High T:AT (%) | 20 (29) | 4 (8) | - | .065 |
Wilcoxon signed-ranks test was used for continuous variables and McNemar test was used for categorical variables. The 95% CIs of absolute differences were calculated using bootstrapping. High is defined as above normal range.
α1AT, α1-antitrypsin; aPTT, activated partial thromboplastin time; AT, antithrombin; C1Inh, C1 esterase inhibitor; FIXa, activated factor IX; FVIIa, activated FVII; FXa, activated factor X; FXIa, activated factor XI; FXIIa, activated factor XII; PT, prothrombin time; T:AT, thrombin in complex with antithrombin.
D-dimers normal range for age 50 years or younger, with an incremental increase of 0.1 for each year >50 years.
Statistically significant.