Fig. 2.

Deletion of TSP1 in platelets attenuated diet-induced hyperlipidemia, and improved glucose homeostasis in mice after 32-week AMLN diet feeding.

(A) Schematic diagram of experimental setting for 32 weeks LF or AMLN diet feeding; (B) Body weight and body composition were measured at 32 weeks after LF or AMLN diet feeding; (C) Plasma glucose and HOMA-IR in postprandial condition; (D) Total plasma cholesterol levels and the plasma lipoprotein contribution by fast-performance liquid chromatography. Data are represented as mean ± SE (n = 4-7 mice/group); one-way ANOVA with Tukey’s post hoc test. ∗p <0.05, ∗∗p <0.01 and ∗∗∗p <0.001. BW, body weight; HOMA-IR, homeostatic model assessment of insulin resistance; LF, low fat; NASH, non-alcoholic steatohepatitis; TC, total cholesterol.