FIGURE 3.

Crosstalk between neutrophils and other autologous cells. Myeloid‐derived suppressor cells (MDSCs), a certain type of immature granulocyte and neutrophil that originate from the same progenitors, result in diverse phenotypes because of the stimuli secreted by tumours. Monocytes can be recruited by cytokines released by neutrophils and differentiate into macrophages; in turn, granulocyte colony‐stimulating factor (G‐CSF) and GM‐CSF produced by monocytes can promote the germination of neutrophils. B cell receptor(BCR) and T cell receptor(TCR), which serve as a peculiar receptors, can be specifically recognised and subsequently develop into functional components. chemokine (C‐C motif) ligand 3(CCL3) can recruit dendritic cells to boost the immunisation. Neutrophil extracellular traps (NETs) additionally play a noteworthy role in fostering cellular communication, thereby aiding in the coordination of components within the tumour microenvironment. Phenotypic transformation of fibroblasts in the tumour microenvironment is conducted by NETs generated by mature neutrophils.