Table 2.

Association of A-E/I Quartiles With Mortality: Hazard Ratios and 95% Confidence Intervals

						Model 1		Model 2		Model 3		Model 4
Quartiles	Median [min, max]	N	Person-years	Event, N	Mortality rate, per 1 000 person-years	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
Men, n = 3 260
Q1	0.43 [0.33, 0.46]	815	8 371	29	3.5	1.00	Reference	1.00	Reference	1.00	Reference	1.00	Reference
Q2	0.48 [0.46, 0.50]	815	8 288	50	6.0	1.75	1.10, 2.76	1.27	0.80, 2.02	1.30	0.82, 2.07	1.17	0.73, 1.88
Q3	0.53 [0.50, 0.55]	815	8 251	71	8.6	2.50	1.62, 3.85	1.53	0.98, 2.37	1.38	0.88, 2.16	1.18	0.73, 1.90
Q4	0.60 [0.55, 0.99]	815	7 821	142	18.2	5.37	3.60, 8.00	2.63	1.73, 4.00	2.24	1.44, 3.49	1.76	1.07, 2.91
p for trend						<0.001		<0.001		<0.001		0.011
Women, n = 4 755
Q1	0.53 [0.36, 0.57]	1 189	12 363	25	2.0	1.00	Reference	1.00	Reference	1.00	Reference	1.00	Reference
Q2	0.60 [0.57, 0.62]	1 189	12 341	31	2.5	1.24	0.73, 2.10	1.11	0.66, 1.89	1.07	0.63, 1.82	1.13	0.66, 1.95
Q3	0.65 [0.62, 0.68]	1 189	12 146	41	3.4	1.69	1.03, 2.77	1.37	0.83, 2.27	1.22	0.73, 2.03	1.33	0.78, 2.27
Q4	0.74 [0.68, 1.31]	1 188	12 092	77	6.4	3.19	2.03, 5.01	2.30	1.45, 3.64	1.87	1.14, 3.06	2.19	1.26, 3.79
p for trend						<0.001		0.004		0.004		0.002

Notes: Model 1: unadjusted. Model 2: adjusted for age. Model 3: Model 2 + BMI, smoking status, alcohol consumption, PAL, cancer, CVD, diabetes, and renal failure. Model 4: Model 3 + SMI. A-E/I = appendicular extracellular-to-intracellular water ratio; BMI = body mass index; CI = confidence interval; CVD = cardiovascular disease; HR = hazard ratio; PAL = physical activity level; Q = quartile; SMI = skeletal muscle mass index.