| 1 |
saffron |
decreases the expression
of STAT/JAK circuits |
restricts the cell cycle
in G0/G1 and inhibits cell propagation |
(116,117) |
| 2 |
green tea polyphenols |
suppresses DNA hypermethylation |
blocks tumor growth |
(121) |
| 3 |
diosmetin |
regulates
caspase circuits |
induces
apoptosis |
(123) |
| 4 |
cantharidin |
suppresses MAPK (p38, ERK,
and JNK) |
down-regulates MMP-2/-9 and uPA protein expression |
(128) |
| 5 |
neem |
regulates caspase-3, Bax, caspase-9, and Bcl-2 expression |
promotes apoptosis |
(131) |
| 6 |
cocoa |
induces oxidative stress |
decreases the cell viability
and cell growth |
(134) |
| 7 |
myricetin |
triggers anti-oncogenes (p53) |
restricts
the cell division |
(136) |
| 8 |
silymarin |
up-regulation of
p53 |
increases the
DNA damage |
(140) |
| 9 |
zyflamend |
initiates caspase-9 cleavage |
inhibits
angiogenesis, invasion,
metastasis, and proliferation |
(143) |
| 10 |
rutin |
promotes autophagy and apoptosis |
induces cell mortality |
(147) |
| 11 |
isoliquiritigenin |
inhibits miR-301b |
inhibits cell multiplication |
(150) |
| 12 |
phloretin |
suppresses
expression of
matrix metalloproteinase-9 and inhibits
thymidine |
- |
(153) |
| 13 |
apigenin |
enhances
expression of p53 |
promotes cell apoptosis |
(157) |
| 14 |
baicalein |
down-regulates MMP-9 and MMP-2 expression |
suppresses
invasion and
migration |
(160) |
| 15 |
thymoquinone |
down-regulates DNMT1 |
up-regulates BRCA1 |
(162) |
| 16 |
luteolin |
inhibits epithelial–mesenchymal transition |
blocks
the progression of
SC cells |
(170) |
