Table 2.

The GO terms and associated genes identified using down-regulated genes at 17 week of age compared to the 8 week in treated group.

GO terms	Genes	Adjusted value of p
Lipid metabolic process (GO:0006629; 24 genes)	HMGCS1, HMGCS2, ST6GALNAC6, ACAT1, ACADVL, ACSF2, ALOX15B, CYP51A1, CYB5R1, FDPS, FDFT1, GSTM1, GPX4, GDE1, HSD17B12, ISYNA1, INSIG1, LSS, LIPN, MVD, PRDX6, SPTSSB, SCD, TECR	<<0.00001
Cholesterol biosynthesis (GO:0006695; 8 genes)	HMGCS1, HMGCS2, CYP51A1, FDPS, FDFT1, INSIG1, LSS, MVD	<0.005
Organic acid metabolic process (GO:0006082; 31 genes)	ACAT1, ACAT2, ACADVL, ACSF2, ACOT8, ALDOC, ACY1, ALOX15B, ENO1, FBP1, GGH, GGT1, GOT2, GSTM1, GSTA1, GPX4, HSD17B12, HSD17B8, INSIG1, IDH3A, MDH1, ME2, MTHFD1, ODC1, PGD, PSAT1, PSPH, PYCR1, SHMT2, SCD, TECR	<0.05
Carboxylic acid biosynthetic process (GO:0046394; 31 genes)	ACAT1, ACAT2, ACADVL, ACSF2, ACOT8, ALDOC, ACY1, ALOX15B, ENO1, FBP1, GGH, GGT1, GOT2, GSTM1, GSTA1, GPX4, HSD17B12, HSD17B8, INSIG1, IDH3A, MDH1, ME2, MTHFD1, ODC1, PGD, PSAT1, PSPH, PYCR1, SHMT2, SCD, TECR	<0.001
Organic hydroxy compound metabolic process (GO:1901615; 19 genes)	HMGCS1, HMGCS2, WNT5A, ALOX15B, CLCN2, CYP51A1, CYB5R1, FDPS, FDFT1, GDE1, ISYNA1, INSIG1, LSS, MSMO1, MVD, PGP, PDXP, SPTSSB, SQLE	<0.01