Table 1.
Characteristics of previous cases with APOE Chicago mutation
| Onset age/Sex/Ethnicity | APOE mutations | Clinical data | Family history | Ref | |
|---|---|---|---|---|---|
| Case 1 | 33/Male/Japanese | APOE Chicago, APOE2/ APOE(Glu3Lys) | 24hUP 3-6 g, Alb 30 g/L, eGFR 62.7 ml/(min·1.73m2); kidney transplant at 36 | No | [5, 6] |
| Case 2 | 32/Male/Mexican | APOE Chicago | 24hUP 9.7 g, Alb 29.1 g/L, eGFR 57 ml/(min·1.73m2) | Family history of premature renal failure without gene information | [7] |
| Case 3 | 51/Female/Japanese | APOE Chicago, APOE (Glu3Lys) | Urine albumin/creatinine ratio 4120 mg/g Cr, Alb 36 g/L, eGFR 90 ml/(min·1.73m2) | Patient’s mother with same mutation but no clinical manifestation. | [8] |
| Case 4 | 50/Male/Chinese | APOE Chicago | 24hUP 5.7 g, Alb 31.2 g/L, eGFR 51.9 ml/(min·1.73m2) | No | [9] |
| Case 5 | 7/Male/Chinese | APOE Chicago | 24hUP 2.5 g, Alb 22.3 g/L, eGFR N/A, Cr 48.5µmol/L | Paternal gene mutation; family history of proteinuria and renal failure. | [10] |
APOE apolipoprotein E, 24hUP: 24-hour urine protein, Alb: albumin, Cr: creatinine, eGFR: estimated glomerular filtration rate.