Figure 5.

ADHD polyneuro score associated with ADHD symptoms. Polyneuro scores and residualized ADHD symptom scores, after adjusting for relevant covariates (see Materials and Methods), for all subjects in the (A) ABCD ARMS-2 (N = 2,796) and (B) Oregon-ADHD-1000 cohort, using each subject’s earliest scan (N = 494). C, The proportion of ADHD symptom score variance explained in the Oregon cohort, by the single most significantly associated connection (Min-p); polyneuro scores comprised of the top 1%, 10%, and 50% most significant connections; and all connections (bootstrapped standard errors are shown). D, Subjects in the Oregon-ADHD-1000 cohort with persistent ADHD showed higher ADHD PNRS than controls (p = 0.00142), though this difference decreases with age. PNRS_U, unadjusted polyneuro score; PNRS_B, Bayesian-adjusted polyneuro score.