Table 2.

Risks of mental health disorders among prostate cancer survivors compared with the general population^a

	HRs for mental health disorders			Estimatesb
Diagnosis		No. at risk, prostate cancer	No. at risk, general population	HR (95% CI)
Mental illness
0-2 yc		11 854	46 602	1.68 (1.61 to 1.76)
2-5 y		9158	40 266	1.05 (1.01 to 1.08)
5-10 y		6202	27 253	1.02 (0.98 to 1.06)
10-16 y		3084	12 860	0.99 (0.93 to 1.05)
Adjustment disorder
0-2 y		18 010	72 803	1.69 (1.28 to 2.24)
2-5 y		17 876	72 266	1.25 (0.95 to 1.65)
5-10 y		12 130	46 829	1.48 (1.15 to 1.90)
10-16 y		5395	19 787	1.25 (0.83 to 1.88)
Anxiety disorder
0-2 y		16 318	65 615	1.37 (1.25 to 1.49)
2-5 yc		15 978	63 649	1.20 (1.12 to 1.28)
5-10 y		10 370	40 955	1.20 (1.12 to 1.29)
10-16 y		4758	17 814	1.29 (1.14 to 1.45)
Delirium, dementia, and cognitive disorders
0-2 yc		17 625	70 582	0.74 (0.67 to 0.82)
2-5 y		11 854	46 602	0.79 (0.69 to 0.90)
5-10 y		11 604	44 997	0.95 (0.87 to 1.03)
10-16 y		5266	19 422	1.01 (0.88 to 1.16)
Mood disorders
0-2 yc		15 881	63 227	1.38 (1.28 to 1.50)
2-5 y		16 108	63 871	1.21 (1.14 to 1.29)
5-10 y		9989	39 606	1.20 (1.13 to 1.28)
10-16 y		4621	17 367	1.25 (1.12 to 1.38)
Bipolar disorders
0-2 yc		17 876	72 266	1.38 (0.92 to 2.05)
2-5 y		16 443	65 603	1.23 (0.90 to 1.69)
5-10 y		11 994	46 464	0.97 (0.65 to 1.45)
10-16 y		5357	19 670	1.28 (0.35 to 4.78)
Depressive disorder
0-2 yc		15 978	63 649	2.05 (1.80 to 2.33)
2-5 y		14 217	57 253	1.16 (1.03 to 1.31)
5-10 y		10 147	40 181	1.15 (1.00 to 1.34)
10-16 y		4637	17 437	1.35 (0.94 to 1.94)
Schizophrenia and other psychotic disorders
0-2 y		17 863	71 823	0.84 (0.71 to 1.00)
2-5 y		16 739	66 707	0.82 (0.70 to 0.96)
5-10 y		11 932	46 023	0.96 (0.82 to 1.13)
10-16 y		5349	19 620	1.14 (0.77 to 1.69)
Alcohol-related disorders
0-2 yc		17 646	70 546	0.85 (0.71 to 1.01)
2-5 y		16 746	66 721	0.80 (0.69 to 0.92)
5-10 y		11 825	45 351	1.08 (0.94 to 1.25)
10-16 y		5303	19 351	0.97 (0.73 to 1.29)
Substance-related disorders
0-2 yc		17 805	71 236	0.89 (0.75 to 1.05)
2-5 y		14 028	56 599	0.80 (0.71 to 0.91)
5-10 y		11 900	45 511	0.62 (0.55 to 0.70)
10-16 y		5362	19 566	0.73 (0.60 to 0.88)
Suicide and intentional self-inflicted injury
0-2 y		18 032	72 804	0.95 (0.70 to 1.29)
2-5 y		16 704	66 473	1.12 (0.85 to 1.47)
5-10 y		12 159	46 852	0.82 (0.61 to 1.10)
10-16 y		5413	19 816	1.44 (0.85 to 2.43)

^aAll hazard ratios were adjusted for age, birth state, baseline body mass index, baseline Carlson Comorbidity Index, and race and ethnicity. CI = confidence interval; HR = hazard ratio.

^bBold values indicate statistical significance (P < .05).

^cProportional hazards assumption not met; flexible spline model used.