Table 2.
Incidence rates and male-to-female incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for cancer among transplant recipients and in the general US population standardized to transplant populationa
| Incidence in transplant recipients, per 100 000 person-years |
Incidence in the general population, per 100 000 person-years |
M:F IRRTransplant (95% CI) | M:F IRRGP | P-value for differenceb | |||
|---|---|---|---|---|---|---|---|
| Cancer site | Males | Females | Males | Females | |||
| Lip | 16.6 | 9.2 | 1.9 | 0.5 | 1.81 (1.37 to 2.38) | 3.96 | <.0001 |
| Oral cavity | 22.6 | 12.2 | 11.5 | 5.2 | 1.85 (1.46 to 2.34) | 2.23 | .121 |
| Oropharynx | 0.4 | 0.3 | 0.4 | 0.1 | 1.62 (0.31 to 8.33) | 3.29 | .399 |
| Esophagus | 21.1 | 5.6 | 14.4 | 3.1 | 3.77 (2.72 to 5.23) | 4.59 | .238 |
| Adenocarcinoma | 13.3 | 1.5 | 9.2 | 1.1 | 9.11 (4.94 to 16.78) | 8.74 | .894 |
| Squamous cell carcinoma | 6.7 | 3.7 | 4.3 | 1.9 | 1.80 (1.17 to 2.77) | 2.29 | .273 |
| Stomach | 26.1 | 17.3 | 17.5 | 8.4 | 1.51 (1.23 to 1.85) | 2.09 | .002 |
| Colorectum | 73.1 | 74.3 | 85.6 | 59.7 | 0.98 (0.89 to 1.10) | 1.43 | <.0001 |
| Proximal colon | 36.1 | 44.1 | 30.2 | 25.5 | 0.82 (0.71 to 0.95) | 1.18 | <.0001 |
| Distal colon | 18.6 | 14.5 | 24.2 | 15.7 | 1.28 (1.02 to 1.61) | 1.54 | .112 |
| Rectum | 15.3 | 12.1 | 28.8 | 16.9 | 1.26 (0.98 to 1.63) | 1.71 | .019 |
| Liver | 35.3 | 14.8 | 26.4 | 7.7 | 2.39 (1.94 to 2.95) | 3.44 | .002 |
| Larynx | 20.3 | 5.6 | 11.7 | 2.4 | 3.63 (2.62 to 5.04) | 4.97 | .060 |
| Lung | 212.5 | 160.1 | 113.4 | 82.0 | 1.33 (1.24 to 1.42) | 1.38 | .286 |
| Adenocarcinoma | 70.9 | 69.9 | 44.6 | 39.1 | 1.02 (0.91 to 1.13) | 1.14 | .044 |
| Squamous cell carcinoma | 79.8 | 45.4 | 27.2 | 12.6 | 1.76 (1.55 to 1.99) | 2.15 | .002 |
| Small cell carcinoma | 20.3 | 13.2 | 14.4 | 11.6 | 1.54 (1.22 to 1.95) | 1.25 | .081 |
| Kidney | 147.4 | 88.5 | 38.7 | 17.2 | 1.67 (1.52 to 1.82) | 2.24 | <.0001 |
| Bladder | 39.5 | 19.6 | 55.3 | 13.2 | 2.02 (1.68 to 2.43) | 4.19 | <.0001 |
| Thyroid | 24.3 | 49.9 | 11.0 | 27.1 | 0.49 (0.42 to 0.57) | 0.41 | .022 |
| Melanoma skin | 66.8 | 33.7 | 48.1 | 26.7 | 1.99 (1.72 to 2.29) | 1.80 | .169 |
| Kaposi sarcomac | 12.4 | 6.9 | 0.4 | 0.1 | 1.79 (1.30 to 2.46) | 3.26 | .0009 |
| Non-Hodgkin lymphoma | 180.5 | 134.7 | 53.8 | 32.9 | 1.34 (1.24 to 1.45) | 1.64 | <.0001 |
| Diffuse large B-cell lymphomah | 110.4 | 88.4 | 14.4 | 9.1 | 1.25 (1.14 to 1.37) | 1.59 | <.0001 |
a
M:F IRRGP estimates are standardized to the transplant population on age, race and ethnicity, and year of diagnosis. M:F IRR = male to female incidence rate ratio.
b
P-values were estimated from a chi-square test using the formula log (M:F IRRTransplant—IRRGP)2/Var(M:F IRRTransplant)2 with 1 degree of freedom.
c
Estimates of the M:F IRRTransplant were restricted to non-Hispanic White and non-Hispanic Black participants in SEER9 (1973-1979) to calculate the M:F IRRGP.